Limited clinical role of blood eosinophil levels in early life atopic disease: A mother-child cohort study

Signe Kjeldgaard Jensen, Mathias Elsner Melgaard, Casper-Emil Tingskov Pedersen, Luo Yang, Nilo Vahman, Jacob P. Thyssen, Ann-Marie M Schoos, Jakob Stokholm, Hans Bisgaard, Bo Chawes, Klaus Bønnelykke*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

BACKGROUND: Blood eosinophil count is a well-established biomarker of atopic diseases in older children and adults. However, its predictive role for atopic diseases in preschool children is not well established.

OBJECTIVE: To investigate the association between blood eosinophil count in children and development of atopic diseases up to age 6 years.

METHODS: We investigated blood eosinophil count at age 18 months and 6 years in relation to recurrent wheeze/asthma, atopic dermatitis, allergic rhinitis, and allergic sensitization during the first 6 years of life in the two Copenhagen Prospective Studies on Asthma in Childhood cohorts (n = 1111). Blood eosinophil count was investigated in association with remission of existing atopic disease, current atopic disease, and later development of atopic disease.

RESULTS: Blood eosinophil count at 18 months was not associated with current wheezing/asthma or atopic dermatitis, while blood eosinophil count at age 6 years was associated with increased occurrence of current wheezing/asthma (OR = 1.1; 1.04-1.16, p = .0005), atopic dermatitis (OR = 1.06; 1.01-1.1, p = .02), and allergic rhinitis (OR = 1.11; 1.05-1.18, p = .0002). Blood eosinophil count at 18 months did not predict persistence or development of recurrent wheeze/asthma or atopic dermatitis at age 6 years.

CONCLUSION: Blood eosinophil count at 18 months was not associated with current wheezing/asthma or atopic dermatitis and did not predict persistence or development of disease. This implies a limited clinical role of blood eosinophil levels in early-life atopic disease and questions the clinical value of blood eosinophil counts measured in toddlers as a predictive biomarker for subsequent atopic disease in early childhood.

OriginalsprogEngelsk
Sider (fra-til)e14050
TidsskriftPediatric Allergy and Immunology
Vol/bind34
Udgave nummer11
DOI
StatusUdgivet - nov. 2023

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© 2023 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

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