Left ventricular contractile function after distal protection in primary percutaneous coronary intervention: Results from the Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction trial

K. F. Kofoed, H. Kelbæk, L. Thuesen, S. H. Poulsen, C. Hassager, N. H. Andersen, S. Helqvist, J. F. Lassen, P. Clemmensen, L. Kløvgaard, A. Kaltoft, T. Engstrøm, L. R. Krusell, C. J. Terkelsen, L. Køber

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    Abstrakt

    Background: Coronary intervention (PCI) may result in an increased infarct size. We evaluated the effect of distal protection during PCI for ST-segment elevation myocardial infarction (STEMI) on myocardial function. Methods: Patients with STEMI were randomly referred within 12 h for PCI with (N = 312) or without distal protection (N = 314). Left ventricular (LV) contractile function was assessed with echocardiography 8 months after PCI. Global LV myocardial wall motion index (WMI) was calculated as the average wall motion score of all myocardial segments. The occurrence of death, nonfatal re-infarction, and stroke 8 months after PCI were also recorded. Results: The occurrence of death, nonfatal re-infarction, and stroke 8 months after PCI was 7.1% after distal protection and 5.7% after conventional treatment (p = 0.17). WMI improved by 4.1% at 8 months in patients treated with distal protection compared to patients receiving conventional PCI (p < 0.01). In myocardium supplied by a culprit artery treated by distal protection regional LV function was 9-11% higher than myocardial regions treated conventionally (p < 0.02). Conclusions: Routine use of distal protection during primary PCI is associated with a significant improvement in LV contractile function, with no detectable impact on intermediate term clinical outcome.

    OriginalsprogEngelsk
    Sider (fra-til)395-398
    Antal sider4
    TidsskriftInternational Journal of Cardiology
    Vol/bind146
    Udgave nummer3
    DOI
    StatusUdgivet - 3 feb. 2011

    Fingeraftryk Udforsk hvilke forskningsemner 'Left ventricular contractile function after distal protection in primary percutaneous coronary intervention: Results from the Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction trial' indeholder.

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