Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders

Kristoffer Sølvsten Burgdorf*, Betina B Trabjerg, Marianne Giørtz Pedersen, Janna Nissen, Karina Banasik, Ole Birger Pedersen, Erik Sørensen, Kaspar René Nielsen, Margit Hørup Larsen, Christian Erikstrup, Peter Bruun-Rasmussen, David Westergaard, Lise Wegner Thørner, Henrik Hjalgrim, Helene Martina Paarup, Søren Brunak, Carsten B Pedersen, E Fuller Torrey, Thomas Werge, Preben Bo MortensenRobert H Yolken, Henrik Ullum

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

BACKGROUND: Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior.

METHODS: This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify individuals who have a psychiatric diagnosis (N?=?2591), have attempted or committed suicide (N?=?655), or have had traffic accidents (N?=?2724). For all cases, controls were frequency matched by age and sex, resulting in 11,546 participants. Plasma samples were analyzed for immunoglobulin G (IgG) antibodies against Toxoplasma gondii and cytomegalovirus (CMV).

RESULTS: T. gondii was detected in 25�9% of the population and was associated with schizophrenia (odds ratio [OR], 1�47; 95% confidence interval [CI], 1�03-2�09). Accounting for temporality, with pathogen exposure preceding outcome, the association was even stronger (IRR, 2�78; 95% CI, 1�27-6�09). A very weak association between traffic accident and toxoplasmosis (OR, 1�11; 95% CI, 1�00-1�23, p?=?0.054) was found. CMV was detected in 60�8% of the studied population and was associated with any psychiatric disorder (OR, 1�17; 95% CI, 1�06-1�29), but also with a smaller group of neurotic, stress-related, and somatoform disorders (OR, 1�27; 95% CI, 1�12-1�44), and with attempting or committing suicide (OR, 1�31; 95% CI, 1�10-1�56). Accounting for temporality, any psychiatric disorder (IRR, 1�37; 95% CI, 1�08-1�74) and mood disorders (IRR, 1�43; 95% CI, 1�01-2�04) were associated with exposure to CMV. No association between traffic accident and CMV (OR, 1�06; 95% CI, 0�97-1�17) was found.

CONCLUSIONS: This large-scale serological study is the first study to examine temporality of pathogen exposure and to provide evidence of a causal relationship between T. gondii and schizophrenia, and between CMV and any psychiatric disorder.

OriginalsprogEngelsk
Sider (fra-til)152-158
Antal sider7
TidsskriftBrain, Behavior, and Immunity
Vol/bind79
DOI
StatusUdgivet - jul. 2019

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Copyright � 2019 The Authors. Published by Elsevier Inc. All rights reserved.

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