Lægemiddeludløst systemisk lupus erythematosus

Sofie Døssing; Tanja Todberg; Søren Jacobsen; Henrik Christian  Bidstrup Leffers

doi:10.61409/V10240784

Lægemiddeludløst systemisk lupus erythematosus

Sofie Døssing^*, Tanja Todberg, Søren Jacobsen, Henrik Christian Bidstrup Leffers

^*Corresponding author af dette arbejde

Dermatologisk Afdeling

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

This case report describes a 63-year-old female patient with hypertension who developed drug-induced systemic lupus erythematosus (SLE) after hospitalization for syncope and severe hyponatraemia. Her complex medication regimen, including antihypertensives and proton pump-inhibitors, complicated the identification of a specific trigger. Positive anti-histone antibodies supported the diagnosis. Treatment with immunosuppressants and discontinuation of suspected drugs led to remission. This case highlights the importance of recognizing drug triggers in elderly patients with extensive medication use.

Bidragets oversatte titel	Drug-induced systemic lupus erythematosus
Originalsprog	Dansk
Artikelnummer	V10240784
Antal sider	3
Tidsskrift	Ugeskrift for Laeger
Vol/bind	187
DOI	https://doi.org/10.61409/V10240784
Status	Udgivet - 26 maj 2025

Emneord

Antihypertensive Agents/adverse effects
Female
Humans
Hypertension/drug therapy
Immunosuppressive Agents/therapeutic use
Lupus Erythematosus, Systemic/chemically induced
Middle Aged
Proton Pump Inhibitors/adverse effects

Adgang til dokumentet

10.61409/V10240784Licens: CC BY-NC-ND

Citationsformater

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title = "L{\ae}gemiddeludl{\o}st systemisk lupus erythematosus",

abstract = "This case report describes a 63-year-old female patient with hypertension who developed drug-induced systemic lupus erythematosus (SLE) after hospitalization for syncope and severe hyponatraemia. Her complex medication regimen, including antihypertensives and proton pump-inhibitors, complicated the identification of a specific trigger. Positive anti-histone antibodies supported the diagnosis. Treatment with immunosuppressants and discontinuation of suspected drugs led to remission. This case highlights the importance of recognizing drug triggers in elderly patients with extensive medication use.",

keywords = "Antihypertensive Agents/adverse effects, Female, Humans, Hypertension/drug therapy, Immunosuppressive Agents/therapeutic use, Lupus Erythematosus, Systemic/chemically induced, Middle Aged, Proton Pump Inhibitors/adverse effects",

author = "Sofie D{\o}ssing and Tanja Todberg and S{\o}ren Jacobsen and \{Bidstrup Leffers\}, \{Henrik Christian\}",

note = "Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.",

year = "2025",

month = may,

day = "26",

doi = "10.61409/V10240784",

language = "Dansk",

volume = "187",

journal = "Ugeskrift for Laeger",

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TY - JOUR

T1 - Lægemiddeludløst systemisk lupus erythematosus

AU - Døssing, Sofie

AU - Todberg, Tanja

AU - Jacobsen, Søren

AU - Bidstrup Leffers, Henrik Christian

N1 - Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

PY - 2025/5/26

Y1 - 2025/5/26

N2 - This case report describes a 63-year-old female patient with hypertension who developed drug-induced systemic lupus erythematosus (SLE) after hospitalization for syncope and severe hyponatraemia. Her complex medication regimen, including antihypertensives and proton pump-inhibitors, complicated the identification of a specific trigger. Positive anti-histone antibodies supported the diagnosis. Treatment with immunosuppressants and discontinuation of suspected drugs led to remission. This case highlights the importance of recognizing drug triggers in elderly patients with extensive medication use.

AB - This case report describes a 63-year-old female patient with hypertension who developed drug-induced systemic lupus erythematosus (SLE) after hospitalization for syncope and severe hyponatraemia. Her complex medication regimen, including antihypertensives and proton pump-inhibitors, complicated the identification of a specific trigger. Positive anti-histone antibodies supported the diagnosis. Treatment with immunosuppressants and discontinuation of suspected drugs led to remission. This case highlights the importance of recognizing drug triggers in elderly patients with extensive medication use.

KW - Antihypertensive Agents/adverse effects

KW - Female

KW - Humans

KW - Hypertension/drug therapy

KW - Immunosuppressive Agents/therapeutic use

KW - Lupus Erythematosus, Systemic/chemically induced

KW - Middle Aged

KW - Proton Pump Inhibitors/adverse effects

U2 - 10.61409/V10240784

DO - 10.61409/V10240784

M3 - Artikel

C2 - 40539284

SN - 0041-5782

VL - 187

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

M1 - V10240784

ER -

Lægemiddeludløst systemisk lupus erythematosus

Abstract

Emneord

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