Kombinationsbehandling med fluconazol og andre QTc-forlængende lægemidler forlænger QTc- intervallet

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstrakt

Several drugs have a QTc-prolonging effect and are metabolized by CYP3A4. The combination of QTc-prolonging drugs may act additive of the QTc interval. The risk increases additionally by co-administration of a CYP3A4-inhibiting substrate. This case report describes an incident with QTc prolongation which was probably caused by an interaction induced by a combination of amiodarone, clarithromycin and the CYP3A4-inhibitor fluconazole.

Bidragets oversatte titelCombination therapy with fluconazole and other QTc-prolonging drugs increase the QTc interval
OriginalsprogDansk
Sider (fra-til)V04150371
TidsskriftUgeskrift for laeger
Vol/bind177
Udgave nummer41
StatusUdgivet - 5 okt. 2015

Fingeraftryk Udforsk hvilke forskningsemner 'Kombinationsbehandling med fluconazol og andre QTc-forlængende lægemidler forlænger QTc- intervallet' indeholder.

Citationsformater