Kingella kingae in Pediatric Bone and Joint Infections: The Diagnostic Value of Oropharyngeal Testing

Allan Bybeck Nielsen; Amalie Hundahl; Mette Holm; Katrine Hartung Hansen; Morten S Lindhard; Jonathan P Glenthøj; Luise Borch; Grethe Lemvik; Mads Damkjær; Lise Heilmann Jensen; Tatjana Zaharov; Ulla Hartling; Lisbeth S Schmidt; Ulrikka Nygaard

doi:10.1097/INF.0000000000005029

Kingella kingae in Pediatric Bone and Joint Infections: The Diagnostic Value of Oropharyngeal Testing

Allan Bybeck Nielsen
, Amalie Hundahl
, Mette Holm
, Katrine Hartung Hansen
, Morten S Lindhard
, Jonathan P Glenthøj
, Luise Borch
, Grethe Lemvik
, Mads Damkjær
, Lise Heilmann Jensen
, Tatjana Zaharov
, Ulla Hartling
, Lisbeth S Schmidt
, Ulrikka Nygaard^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

Oropharyngeal Kingella kingae DNA was identified in 16 of 16 children with proven K. kingae bone and joint infection (BJI) (sensitivity 100%; 95% confidence interval: 79-100) and in 33 of 112 with disproven K. kingae BJI (specificity 71%; 95% confidence interval: 61-79). Due to low specificity, we advocate against oropharyngeal K. kingae DNA testing as a diagnostic tool in children suspected of BJI.

Originalsprog	Engelsk
Sider (fra-til)	e87-e89
Antal sider	3
Tidsskrift	Pediatric Infectious Disease Journal
Vol/bind	45
Udgave nummer	3
DOI	https://doi.org/10.1097/INF.0000000000005029
Status	Udgivet - 1 mar. 2026

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10.1097/INF.0000000000005029

Citationsformater

Nielsen, A. B., Hundahl, A., Holm, M., Hansen, K. H., Lindhard, M. S., Glenthøj, J. P., Borch, L., Lemvik, G., Damkjær, M., Jensen, L. H., Zaharov, T., Hartling, U., Schmidt, L. S., & Nygaard, U. (2026). Kingella kingae in Pediatric Bone and Joint Infections: The Diagnostic Value of Oropharyngeal Testing. Pediatric Infectious Disease Journal, 45(3), e87-e89. https://doi.org/10.1097/INF.0000000000005029

@article{de40b9f7c40d4f21829c0bdb40cf4762,

title = "Kingella kingae in Pediatric Bone and Joint Infections: The Diagnostic Value of Oropharyngeal Testing",

abstract = "Oropharyngeal Kingella kingae DNA was identified in 16 of 16 children with proven K. kingae bone and joint infection (BJI) (sensitivity 100\%; 95\% confidence interval: 79-100) and in 33 of 112 with disproven K. kingae BJI (specificity 71\%; 95\% confidence interval: 61-79). Due to low specificity, we advocate against oropharyngeal K. kingae DNA testing as a diagnostic tool in children suspected of BJI.",

keywords = "Humans, Kingella kingae/isolation \& purification, Neisseriaceae Infections/diagnosis, Oropharynx/microbiology, Child, Child, Preschool, Male, Female, Infant, Arthritis, Infectious/microbiology, Sensitivity and Specificity, DNA, Bacterial/genetics, Adolescent",

author = "Nielsen, \{Allan Bybeck\} and Amalie Hundahl and Mette Holm and Hansen, \{Katrine Hartung\} and Lindhard, \{Morten S\} and Glenth{\o}j, \{Jonathan P\} and Luise Borch and Grethe Lemvik and Mads Damkj{\ae}r and Jensen, \{Lise Heilmann\} and Tatjana Zaharov and Ulla Hartling and Schmidt, \{Lisbeth S\} and Ulrikka Nygaard",

year = "2026",

month = mar,

day = "1",

doi = "10.1097/INF.0000000000005029",

language = "English",

volume = "45",

pages = "e87--e89",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "3",

}

Nielsen, AB, Hundahl, A, Holm, M, Hansen, KH, Lindhard, MS, Glenthøj, JP, Borch, L, Lemvik, G, Damkjær, M, Jensen, LH , Zaharov, T, Hartling, U, Schmidt, LS & Nygaard, U 2026, 'Kingella kingae in Pediatric Bone and Joint Infections: The Diagnostic Value of Oropharyngeal Testing', Pediatric Infectious Disease Journal, bind 45, nr. 3, s. e87-e89. https://doi.org/10.1097/INF.0000000000005029

TY - JOUR

T1 - Kingella kingae in Pediatric Bone and Joint Infections

T2 - The Diagnostic Value of Oropharyngeal Testing

AU - Nielsen, Allan Bybeck

AU - Hundahl, Amalie

AU - Holm, Mette

AU - Hansen, Katrine Hartung

AU - Lindhard, Morten S

AU - Glenthøj, Jonathan P

AU - Borch, Luise

AU - Lemvik, Grethe

AU - Damkjær, Mads

AU - Jensen, Lise Heilmann

AU - Zaharov, Tatjana

AU - Hartling, Ulla

AU - Schmidt, Lisbeth S

AU - Nygaard, Ulrikka

PY - 2026/3/1

Y1 - 2026/3/1

N2 - Oropharyngeal Kingella kingae DNA was identified in 16 of 16 children with proven K. kingae bone and joint infection (BJI) (sensitivity 100%; 95% confidence interval: 79-100) and in 33 of 112 with disproven K. kingae BJI (specificity 71%; 95% confidence interval: 61-79). Due to low specificity, we advocate against oropharyngeal K. kingae DNA testing as a diagnostic tool in children suspected of BJI.

AB - Oropharyngeal Kingella kingae DNA was identified in 16 of 16 children with proven K. kingae bone and joint infection (BJI) (sensitivity 100%; 95% confidence interval: 79-100) and in 33 of 112 with disproven K. kingae BJI (specificity 71%; 95% confidence interval: 61-79). Due to low specificity, we advocate against oropharyngeal K. kingae DNA testing as a diagnostic tool in children suspected of BJI.

KW - Humans

KW - Kingella kingae/isolation & purification

KW - Neisseriaceae Infections/diagnosis

KW - Oropharynx/microbiology

KW - Child

KW - Child, Preschool

KW - Male

KW - Female

KW - Infant

KW - Arthritis, Infectious/microbiology

KW - Sensitivity and Specificity

KW - DNA, Bacterial/genetics

KW - Adolescent

U2 - 10.1097/INF.0000000000005029

DO - 10.1097/INF.0000000000005029

M3 - Article

C2 - 41673936

SN - 0891-3668

VL - 45

SP - e87-e89

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 3

ER -

Kingella kingae in Pediatric Bone and Joint Infections: The Diagnostic Value of Oropharyngeal Testing

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