Kidney replacement therapy for men and women according to the ERA Registry and the USRDS

Vianda S. Stel; Nicholas C Chesnaye; Rianne Boenink; Brittany A Boerstra; Megan E Astley; Shona Methven; Line Heylen; Halima Resic; Marc A G J Ten Dam; Kristine Hommel; Marit D Solbu; Maria F Slon Roblero; Nuria Aresté-Fosalba; Danilo Radunovic; Héctor García López; Lukas Buchwinkler; Rebecca Guidotti; Mathilde Lassalle; Carmen Santiuste; Maria E Stendahl; Olafur S Indridason; Almudena Escribá; María Encarnación Bouzas-Caamaño; Olga Lucía Rodriguez Arévalo; George Moustakas; Hermann Hernández Vargas; Alberto Ortiz; Anneke Kramer

doi:10.1093/ndt/gfaf233

Kidney replacement therapy for men and women according to the ERA Registry and the USRDS

Vianda S. Stel
, Nicholas C Chesnaye
, Rianne Boenink
, Brittany A Boerstra
, Megan E Astley
, Shona Methven
, Line Heylen
, Halima Resic
, Marc A G J Ten Dam
, Kristine Hommel
, Marit D Solbu
, Maria F Slon Roblero
, Nuria Aresté-Fosalba
, Danilo Radunovic
, Héctor García López
, Lukas Buchwinkler
, Rebecca Guidotti
, Mathilde Lassalle
, Carmen Santiuste
, Maria E Stendahl

Olafur S Indridason, Almudena Escribá, María Encarnación Bouzas-Caamaño, Olga Lucía Rodriguez Arévalo, George Moustakas, Hermann Hernández Vargas, Alberto Ortiz, Anneke Kramer^*

^*Corresponding author af dette arbejde

Medicin 1

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

BACKGROUND: This paper compares the incidence and prevalence of kidney replacement therapy (KRT), kidney transplantation rates, and mortality on KRT between Europe and the United States (US), including sex comparisons.

METHODS: Data were derived for 2022 from the population-based European Renal Association (ERA) Registry and the United States Renal Data System (USRDS).

RESULTS: In 2022, the KRT incidence in the US (388.7 per million population (pmp)) was 2.7-fold higher than in Europe (146.2 pmp), with a greater difference for women (3.2-fold) than for men (2.4-fold). The proportion of women initiating KRT was lower in Europe (35%) than in the US (41%). Between 2013 and 2022, the KRT incidence in Europe was stable in women (+0.1% annually), but increased in men (+1.1%). In the US, the KRT incidence increased similarly in women (+0.2%) and men (+0.3%). On 31 December 2022, the KRT prevalence was 2-fold (women: 2.2-fold, men: 1.9-fold) higher in the US (2444.2 pmp) than in Europe (1218.6 pmp). The proportion of women was lower in Europe (38%) than in the US (41%). The kidney transplantation rate was 1.7-fold higher in the US (79.1 pmp) than in Europe (45.4 pmp), 1.9-fold for women and 1.7-fold for men, with women accounting for 37% of the recipients versus 39% in the US. The KRT mortality rate was 1.5 times higher in the US (145.0 per 1000 patient years (/1000py)) compared to Europe (100.5/1000py): 1.6-fold for women and 1.4-fold for men. In Europe, mortality was lower for women receiving KRT (93.7/1000py) than for men (104.6/1000py), whereas in the US the reverse was (women: 148.9/1000py, men: 142.2/1000py).

CONCLUSION: The US had a notably higher KRT incidence, prevalence, kidney transplantation rate and mortality compared to Europe. Differences between Europe and the US were larger for women than for men.

Originalsprog	Engelsk
Antal sider	11
Tidsskrift	Nephrology Dialysis Transplantation
DOI	https://doi.org/10.1093/ndt/gfaf233
Status	Udgivet, E-publikation før trykning - 31 okt. 2025

Adgang til dokumentet

10.1093/ndt/gfaf233

Citationsformater

Stel, V. S., Chesnaye, N. C., Boenink, R., Boerstra, B. A., Astley, M. E., Methven, S., Heylen, L., Resic, H., Ten Dam, M. A. G. J., Hommel, K., Solbu, M. D., Roblero, M. F. S., Aresté-Fosalba, N., Radunovic, D., López, H. G., Buchwinkler, L., Guidotti, R., Lassalle, M., Santiuste, C., ... Kramer, A. (2025). Kidney replacement therapy for men and women according to the ERA Registry and the USRDS. Nephrology Dialysis Transplantation. Advance online publication. https://doi.org/10.1093/ndt/gfaf233

@article{634554a0333d464b9f3f6a440d529add,

title = "Kidney replacement therapy for men and women according to the ERA Registry and the USRDS",

abstract = "BACKGROUND: This paper compares the incidence and prevalence of kidney replacement therapy (KRT), kidney transplantation rates, and mortality on KRT between Europe and the United States (US), including sex comparisons.METHODS: Data were derived for 2022 from the population-based European Renal Association (ERA) Registry and the United States Renal Data System (USRDS).RESULTS: In 2022, the KRT incidence in the US (388.7 per million population (pmp)) was 2.7-fold higher than in Europe (146.2 pmp), with a greater difference for women (3.2-fold) than for men (2.4-fold). The proportion of women initiating KRT was lower in Europe (35\%) than in the US (41\%). Between 2013 and 2022, the KRT incidence in Europe was stable in women (+0.1\% annually), but increased in men (+1.1\%). In the US, the KRT incidence increased similarly in women (+0.2\%) and men (+0.3\%). On 31 December 2022, the KRT prevalence was 2-fold (women: 2.2-fold, men: 1.9-fold) higher in the US (2444.2 pmp) than in Europe (1218.6 pmp). The proportion of women was lower in Europe (38\%) than in the US (41\%). The kidney transplantation rate was 1.7-fold higher in the US (79.1 pmp) than in Europe (45.4 pmp), 1.9-fold for women and 1.7-fold for men, with women accounting for 37\% of the recipients versus 39\% in the US. The KRT mortality rate was 1.5 times higher in the US (145.0 per 1000 patient years (/1000py)) compared to Europe (100.5/1000py): 1.6-fold for women and 1.4-fold for men. In Europe, mortality was lower for women receiving KRT (93.7/1000py) than for men (104.6/1000py), whereas in the US the reverse was (women: 148.9/1000py, men: 142.2/1000py).CONCLUSION: The US had a notably higher KRT incidence, prevalence, kidney transplantation rate and mortality compared to Europe. Differences between Europe and the US were larger for women than for men.",

keywords = "Epidemiology, Incidence, Kidney replacement therapy, Mortality, Prevalence",

author = "Stel, \{Vianda S.\} and Chesnaye, \{Nicholas C\} and Rianne Boenink and Boerstra, \{Brittany A\} and Astley, \{Megan E\} and Shona Methven and Line Heylen and Halima Resic and \{Ten Dam\}, \{Marc A G J\} and Kristine Hommel and Solbu, \{Marit D\} and Roblero, \{Maria F Slon\} and Nuria Arest{\'e}-Fosalba and Danilo Radunovic and L{\'o}pez, \{H{\'e}ctor Garc{\'i}a\} and Lukas Buchwinkler and Rebecca Guidotti and Mathilde Lassalle and Carmen Santiuste and Stendahl, \{Maria E\} and Indridason, \{Olafur S\} and Almudena Escrib{\'a} and Bouzas-Caama{\~n}o, \{Mar{\'i}a Encarnaci{\'o}n\} and Ar{\'e}valo, \{Olga Luc{\'i}a Rodriguez\} and George Moustakas and Vargas, \{Hermann Hern{\'a}ndez\} and Alberto Ortiz and Anneke Kramer",

note = "{\textcopyright} The Author(s) 2025. Published by Oxford University Press on behalf of the ERA.",

year = "2025",

month = oct,

day = "31",

doi = "10.1093/ndt/gfaf233",

language = "English",

journal = "Nephrology Dialysis Transplantation",

issn = "0931-0509",

publisher = "Oxford University Press",

}

Stel, VS, Chesnaye, NC, Boenink, R, Boerstra, BA, Astley, ME, Methven, S, Heylen, L, Resic, H, Ten Dam, MAGJ, Hommel, K, Solbu, MD, Roblero, MFS, Aresté-Fosalba, N, Radunovic, D, López, HG, Buchwinkler, L, Guidotti, R, Lassalle, M, Santiuste, C, Stendahl, ME, Indridason, OS, Escribá, A, Bouzas-Caamaño, ME, Arévalo, OLR, Moustakas, G, Vargas, HH, Ortiz, A & Kramer, A 2025, 'Kidney replacement therapy for men and women according to the ERA Registry and the USRDS', Nephrology Dialysis Transplantation. https://doi.org/10.1093/ndt/gfaf233

TY - JOUR

T1 - Kidney replacement therapy for men and women according to the ERA Registry and the USRDS

AU - Stel, Vianda S.

AU - Chesnaye, Nicholas C

AU - Boenink, Rianne

AU - Boerstra, Brittany A

AU - Astley, Megan E

AU - Methven, Shona

AU - Heylen, Line

AU - Resic, Halima

AU - Ten Dam, Marc A G J

AU - Hommel, Kristine

AU - Solbu, Marit D

AU - Roblero, Maria F Slon

AU - Aresté-Fosalba, Nuria

AU - Radunovic, Danilo

AU - López, Héctor García

AU - Buchwinkler, Lukas

AU - Guidotti, Rebecca

AU - Lassalle, Mathilde

AU - Santiuste, Carmen

AU - Stendahl, Maria E

AU - Indridason, Olafur S

AU - Escribá, Almudena

AU - Bouzas-Caamaño, María Encarnación

AU - Arévalo, Olga Lucía Rodriguez

AU - Moustakas, George

AU - Vargas, Hermann Hernández

AU - Ortiz, Alberto

AU - Kramer, Anneke

PY - 2025/10/31

Y1 - 2025/10/31

N2 - BACKGROUND: This paper compares the incidence and prevalence of kidney replacement therapy (KRT), kidney transplantation rates, and mortality on KRT between Europe and the United States (US), including sex comparisons.METHODS: Data were derived for 2022 from the population-based European Renal Association (ERA) Registry and the United States Renal Data System (USRDS).RESULTS: In 2022, the KRT incidence in the US (388.7 per million population (pmp)) was 2.7-fold higher than in Europe (146.2 pmp), with a greater difference for women (3.2-fold) than for men (2.4-fold). The proportion of women initiating KRT was lower in Europe (35%) than in the US (41%). Between 2013 and 2022, the KRT incidence in Europe was stable in women (+0.1% annually), but increased in men (+1.1%). In the US, the KRT incidence increased similarly in women (+0.2%) and men (+0.3%). On 31 December 2022, the KRT prevalence was 2-fold (women: 2.2-fold, men: 1.9-fold) higher in the US (2444.2 pmp) than in Europe (1218.6 pmp). The proportion of women was lower in Europe (38%) than in the US (41%). The kidney transplantation rate was 1.7-fold higher in the US (79.1 pmp) than in Europe (45.4 pmp), 1.9-fold for women and 1.7-fold for men, with women accounting for 37% of the recipients versus 39% in the US. The KRT mortality rate was 1.5 times higher in the US (145.0 per 1000 patient years (/1000py)) compared to Europe (100.5/1000py): 1.6-fold for women and 1.4-fold for men. In Europe, mortality was lower for women receiving KRT (93.7/1000py) than for men (104.6/1000py), whereas in the US the reverse was (women: 148.9/1000py, men: 142.2/1000py).CONCLUSION: The US had a notably higher KRT incidence, prevalence, kidney transplantation rate and mortality compared to Europe. Differences between Europe and the US were larger for women than for men.

AB - BACKGROUND: This paper compares the incidence and prevalence of kidney replacement therapy (KRT), kidney transplantation rates, and mortality on KRT between Europe and the United States (US), including sex comparisons.METHODS: Data were derived for 2022 from the population-based European Renal Association (ERA) Registry and the United States Renal Data System (USRDS).RESULTS: In 2022, the KRT incidence in the US (388.7 per million population (pmp)) was 2.7-fold higher than in Europe (146.2 pmp), with a greater difference for women (3.2-fold) than for men (2.4-fold). The proportion of women initiating KRT was lower in Europe (35%) than in the US (41%). Between 2013 and 2022, the KRT incidence in Europe was stable in women (+0.1% annually), but increased in men (+1.1%). In the US, the KRT incidence increased similarly in women (+0.2%) and men (+0.3%). On 31 December 2022, the KRT prevalence was 2-fold (women: 2.2-fold, men: 1.9-fold) higher in the US (2444.2 pmp) than in Europe (1218.6 pmp). The proportion of women was lower in Europe (38%) than in the US (41%). The kidney transplantation rate was 1.7-fold higher in the US (79.1 pmp) than in Europe (45.4 pmp), 1.9-fold for women and 1.7-fold for men, with women accounting for 37% of the recipients versus 39% in the US. The KRT mortality rate was 1.5 times higher in the US (145.0 per 1000 patient years (/1000py)) compared to Europe (100.5/1000py): 1.6-fold for women and 1.4-fold for men. In Europe, mortality was lower for women receiving KRT (93.7/1000py) than for men (104.6/1000py), whereas in the US the reverse was (women: 148.9/1000py, men: 142.2/1000py).CONCLUSION: The US had a notably higher KRT incidence, prevalence, kidney transplantation rate and mortality compared to Europe. Differences between Europe and the US were larger for women than for men.

KW - Epidemiology

KW - Incidence

KW - Kidney replacement therapy

KW - Mortality

KW - Prevalence

U2 - 10.1093/ndt/gfaf233

DO - 10.1093/ndt/gfaf233

M3 - Article

C2 - 41172240

SN - 0931-0509

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

ER -

Kidney replacement therapy for men and women according to the ERA Registry and the USRDS

Abstract

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