TY - JOUR
T1 - Ischemic Heart Disease in Chronic Hepatitis B
T2 - A Danish Nationwide Cohort Study
AU - Lau, Frederik Faergemann
AU - Bollerup, Signe
AU - Engsig, Frederik
AU - Krarup, Henrik
AU - Mygind, Lone Hagens
AU - Hansen, Jesper Bach
AU - Madsen, Lone Galmstrup
AU - Thielsen, Peter
AU - Balslev, Ulla
AU - Nielsen, Lars Nørregaard
AU - Barfod, Toke S
AU - Clausen, Mette Rye
AU - Hobolth, Lise
AU - Laursen, Alex Lund
AU - Tarp, Britta
AU - Roege, Birgit T
AU - Gerstoft, Jan
AU - Christensen, Peer Brehm
AU - Weis, Nina
N1 - © 2022 Lau et al.
PY - 2022/12/18
Y1 - 2022/12/18
N2 - Objective: Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population.Study Design and Setting: We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model.Results: In total, 6472 persons with CHB and 62,251 age- and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59%) with CHB and 1058 (1,70%) control-persons developed IHD. The crude IRR was 1.13 (95% CI: 0.91-1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95% CI: 0.76-1.21).Conclusion: In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.
AB - Objective: Data on the risk of ischemic heart disease (IHD) in patients with chronic hepatitis B virus (CHB) are conflicting. Our objective was to address the rate of IHD in patients with CHB compared with individuals without CHB (control-persons) from the general population.Study Design and Setting: We conducted a cohort study of prospectively obtained data from Danish nationwide registries. We produced cumulative incidence curves and calculated the unadjusted incidence rate ratio (IRR) of IHD in persons with and without CHB. The adjusted association between having CHB and developing IHD was examined using a cause-specific Cox regression model.Results: In total, 6472 persons with CHB and 62,251 age- and sex-matched individuals from the general population were followed for 48,840 and 567,456 person-years, respectively, during which 103 (1,59%) with CHB and 1058 (1,70%) control-persons developed IHD. The crude IRR was 1.13 (95% CI: 0.91-1.39). CHB did not have a statistically significant effect on the rate of IHD after adjusting for several confounding factors (adjusted hazard ratio: 0.96, 95% CI: 0.76-1.21).Conclusion: In this nationwide cohort study, we did not find any difference between rate of IHD in persons with CHB in comparison with the general population.
U2 - 10.2147/CLEP.S361910
DO - 10.2147/CLEP.S361910
M3 - Article
C2 - 35879942
SN - 1179-1349
VL - 14
SP - 879
EP - 888
JO - Clinical Epidemiology
JF - Clinical Epidemiology
ER -