Irritable bowel syndrome, the microbiota and the gut-brain axis

Hans Raskov*, Jakob Burcharth, Hans Christian Pommergaard, Jacob Rosenberg

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review


Irritable bowel syndrome is a common functional gastrointestinal disorder and it is now evident that irritable bowel syndrome is a multi-factorial complex of changes in microbiota and immunology. The bidirectional neurohumoral integrated communication between the microbiota and the autonomous nervous system is called the gut-brain-axis, which integrates brain and GI functions, such as gut motility, appetite and weight. The gut-brain-axis has a central function in the perpetuation of irritable bowel syndrome and the microbiota plays a critical role. The purpose of this article is to review recent research concerning the epidemiology of irritable bowel syndrome, influence of microbiota, probiota, gut-brain-axis, and possible treatment modalities on irritable bowel syndrome.

Sider (fra-til)365-383
Antal sider19
TidsskriftGut Microbes
Udgave nummer5
StatusUdgivet - 2 sep. 2016


Udforsk hvilke forskningsemner 'Irritable bowel syndrome, the microbiota and the gut-brain axis' indeholder.