Several studies demonstrated a pronounced dietary influence on the fibrinolytic system of obese, hyperlipemic, and healthy individuals, and suggested that the complex dietary change from a typical Western highfat diet to a low saturated fat, high-fibre diet causes an enhancement of endogenous fibrinolysis. An independent effect of particular nutrients and foods was observed in other studies. The consumption of diets rich in fatty fish, and dietary supplementation with fish oil were repeatedly shown to increase PAI-1 levels. These findings indicate that the marine n-3 polyunsaturated fatty acids inhibit the fibrinolytic system. On the contrary, certain soluble dietary fibres if eaten in large amounts as a dietary supplement seem to lower PAI-1 levels. Experimental observations furthermore suggest alcohol to be antifibrinolytic, and garlic to be pro-fibrinolytic, whereas the total fat content of a diet and the dietary contents of saturated fatty acids and n-6 polyunsaturated fatty acids apparently have no independent effects on fibrinolysis. The available evidence indicates that dietary modification of endogenous fibrinolysis might be of relevance for the prevention and treatment of atherothrombotic disease.