Intestinale bivirkninger relateret til COX-2-hæmmere

Nadia Calvo, Esben Iversen, Lars Kristian Munck*

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstract

    COX-2 inhibitors and NSAIDs have similar analgesic, anti-inflammatory and severe upper intestinal side effects. Adding to the sparse and casuistic reports, a further five cases of severe lower intestinal illness associated with COX-2 inhibitor ingestion are presented. Diarrhoea due to microscopic colitis was associated with short-time ingestion of refecoxib and celecoxib by two patients. Refecoxib intake for two months was associated with spontaneous perforation of a well-functioning J-pouch in a patient with ulcerative colitis. Intake of celecoxib and etodolac was associated with colonic ulceration and stricture. Side effects related to COX-2 inhibitors are similar to those related to NSAIDs.

    Bidragets oversatte titelIntestinal side effects of COX-2 inhibitors
    OriginalsprogDansk
    Sider (fra-til)1343-1344
    Antal sider2
    TidsskriftUgeskrift for laeger
    Vol/bind168
    Udgave nummer13
    StatusUdgivet - 27 mar. 2006

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