Intestinal transport of potassium. Effects of changing apical and basolateral influx of sodium in the isolated mucosa of the hen (Callus domesticus) colon

Lars K. Munck; Bjarne G. Munck

doi:10.1016/0300-9629(90)90062-W

Intestinal transport of potassium. Effects of changing apical and basolateral influx of sodium in the isolated mucosa of the hen (Callus domesticus) colon

Lars K. Munck, Bjarne G. Munck^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

1. 1. Net potassium secretion (J_net ^K) by the sodium-depleted hen's colon (low sodium colon) is 0.17 ± 0.07 μmol/cm²·hr Amiloride or ouabain eliminates short circuit currents (I_sc) of 16-20 μmol/cm²· hr without affecting J_sm ^K. 2. 2. In the NaCl-loaded hen's colon (high sodium colon) stimulating I_sc by (a) glucose, (b) amino acids, and inhibiting with (c) ouabain changes J_net ^K from 0.08 ± 0.04 to (a) 0.42 ± 0.07, to (b) 0.60 ± 0.07 to (c) 0.13 ± 0.13 μmol/cm²·hr. 3. 3. In both colonie types theophylline increases and bumetanide decreases J_net ^K by 1 μmol/cm²·hr. 4. 4. Conclusion: Apical membranes of sodium-absorbing and chloride-secreting cells of the high sodium colon are potassium permeable. In the low sodium colon sodium-absorbing cells have potassiumimpermeable apical membranes.

Originalsprog	Engelsk
Sider (fra-til)	181-186
Antal sider	6
Tidsskrift	Comparative Biochemistry and Physiology -- Part A: Physiology
Vol/bind	96
Udgave nummer	1
DOI	https://doi.org/10.1016/0300-9629(90)90062-W
Status	Udgivet - 1990

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title = "Intestinal transport of potassium. Effects of changing apical and basolateral influx of sodium in the isolated mucosa of the hen (Callus domesticus) colon",

abstract = "1. 1. Net potassium secretion (Jnet K) by the sodium-depleted hen's colon (low sodium colon) is 0.17 ± 0.07 μmol/cm2·hr Amiloride or ouabain eliminates short circuit currents (Isc) of 16-20 μmol/cm2· hr without affecting Jsm K. 2. 2. In the NaCl-loaded hen's colon (high sodium colon) stimulating Isc by (a) glucose, (b) amino acids, and inhibiting with (c) ouabain changes Jnet K from 0.08 ± 0.04 to (a) 0.42 ± 0.07, to (b) 0.60 ± 0.07 to (c) 0.13 ± 0.13 μmol/cm2·hr. 3. 3. In both colonie types theophylline increases and bumetanide decreases Jnet K by 1 μmol/cm2·hr. 4. 4. Conclusion: Apical membranes of sodium-absorbing and chloride-secreting cells of the high sodium colon are potassium permeable. In the low sodium colon sodium-absorbing cells have potassiumimpermeable apical membranes.",

author = "Munck, {Lars K.} and Munck, {Bjarne G.}",

year = "1990",

doi = "10.1016/0300-9629(90)90062-W",

language = "English",

volume = "96",

pages = "181--186",

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T1 - Intestinal transport of potassium. Effects of changing apical and basolateral influx of sodium in the isolated mucosa of the hen (Callus domesticus) colon

AU - Munck, Lars K.

AU - Munck, Bjarne G.

PY - 1990

Y1 - 1990

N2 - 1. 1. Net potassium secretion (Jnet K) by the sodium-depleted hen's colon (low sodium colon) is 0.17 ± 0.07 μmol/cm2·hr Amiloride or ouabain eliminates short circuit currents (Isc) of 16-20 μmol/cm2· hr without affecting Jsm K. 2. 2. In the NaCl-loaded hen's colon (high sodium colon) stimulating Isc by (a) glucose, (b) amino acids, and inhibiting with (c) ouabain changes Jnet K from 0.08 ± 0.04 to (a) 0.42 ± 0.07, to (b) 0.60 ± 0.07 to (c) 0.13 ± 0.13 μmol/cm2·hr. 3. 3. In both colonie types theophylline increases and bumetanide decreases Jnet K by 1 μmol/cm2·hr. 4. 4. Conclusion: Apical membranes of sodium-absorbing and chloride-secreting cells of the high sodium colon are potassium permeable. In the low sodium colon sodium-absorbing cells have potassiumimpermeable apical membranes.

AB - 1. 1. Net potassium secretion (Jnet K) by the sodium-depleted hen's colon (low sodium colon) is 0.17 ± 0.07 μmol/cm2·hr Amiloride or ouabain eliminates short circuit currents (Isc) of 16-20 μmol/cm2· hr without affecting Jsm K. 2. 2. In the NaCl-loaded hen's colon (high sodium colon) stimulating Isc by (a) glucose, (b) amino acids, and inhibiting with (c) ouabain changes Jnet K from 0.08 ± 0.04 to (a) 0.42 ± 0.07, to (b) 0.60 ± 0.07 to (c) 0.13 ± 0.13 μmol/cm2·hr. 3. 3. In both colonie types theophylline increases and bumetanide decreases Jnet K by 1 μmol/cm2·hr. 4. 4. Conclusion: Apical membranes of sodium-absorbing and chloride-secreting cells of the high sodium colon are potassium permeable. In the low sodium colon sodium-absorbing cells have potassiumimpermeable apical membranes.

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U2 - 10.1016/0300-9629(90)90062-W

DO - 10.1016/0300-9629(90)90062-W

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AN - SCOPUS:0025315238

VL - 96

SP - 181

EP - 186

JO - Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

JF - Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

SN - 1095-6433

IS - 1

ER -

Intestinal transport of potassium. Effects of changing apical and basolateral influx of sodium in the isolated mucosa of the hen (Callus domesticus) colon

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