Intestinal transport of potassium. Effects of changing apical and basolateral influx of sodium in the isolated mucosa of the hen (Callus domesticus) colon

Lars K. Munck, Bjarne G. Munck

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    Abstrakt

    1. 1. Net potassium secretion (Jnet K) by the sodium-depleted hen's colon (low sodium colon) is 0.17 ± 0.07 μmol/cm2·hr Amiloride or ouabain eliminates short circuit currents (Isc) of 16-20 μmol/cm2· hr without affecting Jsm K. 2. 2. In the NaCl-loaded hen's colon (high sodium colon) stimulating Isc by (a) glucose, (b) amino acids, and inhibiting with (c) ouabain changes Jnet K from 0.08 ± 0.04 to (a) 0.42 ± 0.07, to (b) 0.60 ± 0.07 to (c) 0.13 ± 0.13 μmol/cm2·hr. 3. 3. In both colonie types theophylline increases and bumetanide decreases Jnet K by 1 μmol/cm2·hr. 4. 4. Conclusion: Apical membranes of sodium-absorbing and chloride-secreting cells of the high sodium colon are potassium permeable. In the low sodium colon sodium-absorbing cells have potassiumimpermeable apical membranes.

    OriginalsprogEngelsk
    Sider (fra-til)181-186
    Antal sider6
    TidsskriftComparative Biochemistry and Physiology -- Part A: Physiology
    Vol/bind96
    Udgave nummer1
    DOI
    StatusUdgivet - 1990

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Intestinal transport of potassium. Effects of changing apical and basolateral influx of sodium in the isolated mucosa of the hen (Callus domesticus) colon' indeholder.

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