Influenza A virus potentiates bacteria‐induced histamine release: Examination of normal individuals and patients allergic to bacteria

P. Clementsen*, M. Pedersen, H. Permin, F. Espersen, S. Norn

*Corresponding author af dette arbejde

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    Abstrakt

    Influenza A virus was found to enhance basophil histamine release induced by Escherichia coli, Salmonella entertidis, Staphylococcus aureus, Streptococcus pneumoniae and Streptococcus sanguis, but did not per se release histamine. This potentiating effect of the virus was seen both when the bacteria‐induced mediator release was IgE‐dependent (i.e. patient allergic to bacterium) and when the bacterium caused histamine release by a non‐immunological mechanism independent of IgE (putative sugar‐lectin mediated). Also histamine release induced by other immunological and non‐immunological stimuli, such as anti‐IgE, calcium ionophore or agarose beads was enhanced in the presence of the virus. The potentiating effect of the virus on bacteria‐induced mediator release might be of importance for the conversion from latent to manifest asthma in upper respiratory tract infections.

    OriginalsprogEngelsk
    Sider (fra-til)464-470
    Antal sider7
    TidsskriftAllergy
    Vol/bind45
    Udgave nummer6
    DOI
    StatusUdgivet - aug. 1990

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