Influenza A virus enhances Staphylococcus aureus‐induced basophil histamine release in normal individuals and patients with intrinsic asthma

P. Clemensten, C. B. Jensen, J. O. Jarløv, C. Hannoun, M. Søborg, S. Norn

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Influenza A virus was found to enhance Staphylococcus aureus‐ histamine release in human leukocyte suspensions, but did not per se release histamine. This potentiating effect was found to be similar in cells from normal individuals and from patients with intrinsic asthma. The enhancement of mediator release could be due to viral neuraminidase on the surface of the virus, since a similar potentiating effect was caused by a purified neuraminidase preparation obtained from Vibrio cholerae, and the effect of virus as well as of the purified neuraminidase was completely abolished by a potent neuraminidase inhibitor. The potentiating effect of virus on bacteria‐induced mediator release might be of importance for the conversion from latent to manifest asthma in upper respiratory tract infections.

    OriginalsprogEngelsk
    Sider (fra-til)39-44
    Antal sider6
    TidsskriftAllergy
    Vol/bind44
    Udgave nummer1
    DOI
    StatusUdgivet - jan. 1989

    Fingeraftryk Udforsk hvilke forskningsemner 'Influenza A virus enhances Staphylococcus aureus‐induced basophil histamine release in normal individuals and patients with intrinsic asthma' indeholder.

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