Histamine release was examined in leukocyte suspensions from patients allergic to house dust mite, grass pollen, birch pollen or cat dander. Influenza A virus was found to enhance the antigen‐induced mediator release, but did not cause release of histamine from the cells per se. Also histamine release induced by anti‐IgE in cell suspensions from normal individuals was enhanced by virus. The potentiating effect of influenza A virus might be due to neuraminidase on the surface of virus, since a similar effect was caused by a purified neuraminidase obtained from Vibrio cholerae, and the effect of virus as well as the neuraminidase was completely abolished by a potent neuraminidase inhibitor. The synergistic enhancement in IgE‐mediated histamine release by virus could be of significance for the conversion from latent to manifest asthma.
|Status||Udgivet - jan. 1989|