Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports

Špela Šuler Baglama; Anja Trajber Horvat; Irena Peteln; Gregor Borut Ernst Jemec

doi:10.1159/000528128

Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports

Špela Šuler Baglama^*
, Anja Trajber Horvat
, Irena Peteln
, Gregor Borut Ernst Jemec

^*Corresponding author af dette arbejde

Dermatologisk Afdeling

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.

Originalsprog	Engelsk
Sider (fra-til)	362-367
Antal sider	6
Tidsskrift	Case Reports in Dermatology
Vol/bind	14
Udgave nummer	3
DOI	https://doi.org/10.1159/000528128
Status	Udgivet - 2022

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10.1159/000528128

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title = "Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports",

abstract = "The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.",

author = "Baglama, \{{\v S}pela {\v S}uler\} and \{Trajber Horvat\}, Anja and Irena Peteln and Jemec, \{Gregor Borut Ernst\}",

note = "Copyright {\textcopyright} 2022 by The Author(s). Published by S. Karger AG, Basel.",

year = "2022",

doi = "10.1159/000528128",

language = "English",

volume = "14",

pages = "362--367",

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T1 - Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel

T2 - Two Case Reports

AU - Baglama, Špela Šuler

AU - Trajber Horvat, Anja

AU - Peteln, Irena

AU - Jemec, Gregor Borut Ernst

PY - 2022

Y1 - 2022

N2 - The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.

AB - The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.

U2 - 10.1159/000528128

DO - 10.1159/000528128

M3 - Article

C2 - 36655062

SN - 1662-6567

VL - 14

SP - 362

EP - 367

JO - Case Reports in Dermatology

JF - Case Reports in Dermatology

IS - 3

ER -

Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports

Abstract

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