TY - JOUR
T1 - Increased myelosuppression during cytostatic treatment and pleural effusion in patients with small cell lung cancer
AU - Herrtedt, Jørn
AU - Clementsen, Paul
AU - Hansen, Ole Paaske
PY - 1992/5
Y1 - 1992/5
N2 - 30 patients with small cell lung cancer (SCLC) and malignant pleural effusion were compared with 30 matched patients with SCLC but without pleural effusion. In the 30 with pleural effusion, white blood cell and platelet counts fell significantly after initial chemotherapy, necessitating dose reduction. Of the patients with pleural effusion, 16 developed severe (WHO grade IV) leukopenia, 7 had severe thrombocytopenia, and 2 patients died of infection. Accordingly, exhaustive aspiration of radiologically verified pleural effusion before starting chemotherapy in patients with SCLC is recommended.
AB - 30 patients with small cell lung cancer (SCLC) and malignant pleural effusion were compared with 30 matched patients with SCLC but without pleural effusion. In the 30 with pleural effusion, white blood cell and platelet counts fell significantly after initial chemotherapy, necessitating dose reduction. Of the patients with pleural effusion, 16 developed severe (WHO grade IV) leukopenia, 7 had severe thrombocytopenia, and 2 patients died of infection. Accordingly, exhaustive aspiration of radiologically verified pleural effusion before starting chemotherapy in patients with SCLC is recommended.
UR - http://www.scopus.com/inward/record.url?scp=0026637464&partnerID=8YFLogxK
U2 - 10.1016/0959-8049(92)90459-F
DO - 10.1016/0959-8049(92)90459-F
M3 - Article
C2 - 1320910
AN - SCOPUS:0026637464
VL - 28
SP - 1070
EP - 1073
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 6-7
ER -