Increased mortality in patients with hematologic malignancies treated with proton pump inhibitors: a nationwide cohort study

Adam Vilmar*, Christian Dehlendorff, Søren Friis, Marja Jäättelä, Siri Tvingsholm, Henrik Frederiksen

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

Proton Pump inhibitors (PPIs) are frequently prescribed to cancer patients to prevent gastric mucosal damage. Post-diagnostic PPI use in patients with solid tumors may be associated with increased cancer mortality. However, the hazardous impact of PPIs in patients with hematologic malignancies remains unknown. This association was investigated in a large, retrospective cohort study using data from the Danish nationwide health registries. The outcomes were cancer-specific or non-cancer deaths. We identified 15,320 patients with hematologic malignancies and of these 1811 were identified as post-diagnostic PPI users. PPI users had significantly increased HRs for cancer-specific mortality (HR 1.31; 95% CI, 1.18-1.44) and 1-year cancer-specific mortality (HR 1.50, 95% CI 1.29-1.74) as compared to nonusers. The association between PPI use and increased cancer-specific mortality in Danish patients with hematologic malignancies supports the raised concerns regarding the frequent use of PPIs in cancer patients.

OriginalsprogEngelsk
Sider (fra-til)1451-1457
Antal sider7
TidsskriftLeukemia and Lymphoma
Vol/bind64
Udgave nummer8
Tidlig onlinedato9 jun. 2023
DOI
StatusUdgivet - 2023

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