Increased brain water content in pseudotumour cerebri measured by magnetic resonance imaging of brain water self diffusion

P. Soelberg Sorensen, C. Thomsen, F. Gjerris, J. Schmidt, L. Kjaer, O. Henriksen

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    Abstrakt

    Brain water self diffusion was investigated by magnetic resonance scanning in 7 patients fulfilling conventional diagnostic criteria for pseudotumour cerebri. Quantitative diffusion measurements were obtained using single spin echo pulse sequences with pulsed magnetic field gradients of different magnitude. In all patients the diffusion images showed an increased diffusion in various brain regions when compared with the diffusion coefficients for corresponding regions in healthy subjects. In 3 pseudotumour patients the increased self diffusion was localized to the periventricular regions, while 4 patients had increased diffusion in the whole brain. The findings indicate the presence of increased brain water content both intra- and extracellularly suggesting that patients with pseudotumour have two defects of pathogenetical significance: intracellular water accumulation and increased resistance to cerebrospinal fluid (CSF) outflow leading to an interstiial oedema.

    OriginalsprogEngelsk
    Sider (fra-til)160-164
    Antal sider5
    TidsskriftNeurological Research
    Vol/bind11
    Udgave nummer3
    DOI
    StatusUdgivet - 1 jan. 1989

    Fingeraftryk Udforsk hvilke forskningsemner 'Increased brain water content in pseudotumour cerebri measured by magnetic resonance imaging of brain water self diffusion' indeholder.

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