Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 clone, Denmark, 2023

Thor Bech Johannesen; Charlotte Munkstrup; Sofie Marie Edslev; Sharmin Baig; Stine Nielsen; Tjede Funk; Dennis Karsten Kristensen; Lars Hervig Jacobsen; Signe Fischer Ravn; Niels Bindslev; Sophie Gubbels; Marianne Voldstedlund; Pikka Jokelainen; Søren Hallstrøm; Astrid Rasmussen; Karl Gústaf Kristinsson; David Fuglsang-Damgaard; Ram B Dessau; Agnieszka Barbara Olsén; Christian Salgaard Jensen; Annette Skovby; Svend Ellermann-Eriksen; Thøger Gorm Jensen; Esad Dzajic; Claus Østergaard; Steen Lomborg Andersen; Steen Hoffmann; Peter Henrik Andersen; Marc Stegger

doi:10.2807/1560-7917.ES.2023.28.26.2300291

Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 clone, Denmark, 2023

Thor Bech Johannesen^*, Charlotte Munkstrup, Sofie Marie Edslev, Sharmin Baig, Stine Nielsen, Tjede Funk, Dennis Karsten Kristensen, Lars Hervig Jacobsen, Signe Fischer Ravn, Niels Bindslev, Sophie Gubbels, Marianne Voldstedlund, Pikka Jokelainen, Søren Hallstrøm, Astrid Rasmussen, Karl Gústaf Kristinsson, David Fuglsang-Damgaard, Ram B Dessau, Agnieszka Barbara Olsén, Christian Salgaard JensenAnnette Skovby, Svend Ellermann-Eriksen, Thøger Gorm Jensen, Esad Dzajic, Claus Østergaard, Steen Lomborg Andersen, Steen Hoffmann, Peter Henrik Andersen, Marc Stegger

^*Corresponding author af dette arbejde

Klinisk Mikrobiologisk Afdeling

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

A highly virulent sub-lineage of the Streptococcus pyogenes M1 clone has been rapidly expanding throughout Denmark since late 2022 and now accounts for 30% of the new invasive group A streptococcal infections. We aimed to investigate whether a shift in variant composition can account for the high incidence rates observed over winter 2022/23, or if these are better explained by the impact of COVID-19-related restrictions on population immunity and carriage of group A Streptococcus.

Originalsprog	Engelsk
Tidsskrift	Eurosurveillance
Vol/bind	28
Udgave nummer	26
DOI	https://doi.org/10.2807/1560-7917.ES.2023.28.26.2300291
Status	Udgivet - jun. 2023

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10.2807/1560-7917.ES.2023.28.26.2300291

Citationsformater

Johannesen, T. B., Munkstrup, C., Edslev, S. M., Baig, S., Nielsen, S., Funk, T., Kristensen, D. K., Jacobsen, L. H., Ravn, S. F., Bindslev, N., Gubbels, S., Voldstedlund, M., Jokelainen, P., Hallstrøm, S., Rasmussen, A., Kristinsson, K. G., Fuglsang-Damgaard, D., Dessau, R. B., Olsén, A. B., ... Stegger, M. (2023). Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 clone, Denmark, 2023. Eurosurveillance, 28(26). https://doi.org/10.2807/1560-7917.ES.2023.28.26.2300291

@article{ff9edb738e964eeeb34b8e4c51e71967,

title = "Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 clone, Denmark, 2023",

abstract = "A highly virulent sub-lineage of the Streptococcus pyogenes M1 clone has been rapidly expanding throughout Denmark since late 2022 and now accounts for 30% of the new invasive group A streptococcal infections. We aimed to investigate whether a shift in variant composition can account for the high incidence rates observed over winter 2022/23, or if these are better explained by the impact of COVID-19-related restrictions on population immunity and carriage of group A Streptococcus.",

keywords = "Humans, COVID-19, Streptococcus pyogenes/genetics, Seasons, Streptococcal Infections/epidemiology, Denmark/epidemiology",

author = "Johannesen, {Thor Bech} and Charlotte Munkstrup and Edslev, {Sofie Marie} and Sharmin Baig and Stine Nielsen and Tjede Funk and Kristensen, {Dennis Karsten} and Jacobsen, {Lars Hervig} and Ravn, {Signe Fischer} and Niels Bindslev and Sophie Gubbels and Marianne Voldstedlund and Pikka Jokelainen and S{\o}ren Hallstr{\o}m and Astrid Rasmussen and Kristinsson, {Karl G{\'u}staf} and David Fuglsang-Damgaard and Dessau, {Ram B} and Ols{\'e}n, {Agnieszka Barbara} and Jensen, {Christian Salgaard} and Annette Skovby and Svend Ellermann-Eriksen and Jensen, {Th{\o}ger Gorm} and Esad Dzajic and Claus {\O}stergaard and {Lomborg Andersen}, Steen and Steen Hoffmann and Andersen, {Peter Henrik} and Marc Stegger",

year = "2023",

month = jun,

doi = "10.2807/1560-7917.ES.2023.28.26.2300291",

language = "English",

volume = "28",

journal = "Eurosurveillance",

issn = "1560-7917",

publisher = "European Centre for Disease Prevention and Control (ECDC)",

number = "26",

}

Johannesen, TB, Munkstrup, C, Edslev, SM, Baig, S, Nielsen, S, Funk, T, Kristensen, DK, Jacobsen, LH, Ravn, SF, Bindslev, N, Gubbels, S, Voldstedlund, M, Jokelainen, P, Hallstrøm, S, Rasmussen, A, Kristinsson, KG, Fuglsang-Damgaard, D, Dessau, RB, Olsén, AB, Jensen, CS, Skovby, A, Ellermann-Eriksen, S, Jensen, TG, Dzajic, E, Østergaard, C, Lomborg Andersen, S, Hoffmann, S, Andersen, PH & Stegger, M 2023, 'Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 clone, Denmark, 2023', Eurosurveillance, bind 28, nr. 26. https://doi.org/10.2807/1560-7917.ES.2023.28.26.2300291

TY - JOUR

T1 - Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 clone, Denmark, 2023

AU - Johannesen, Thor Bech

AU - Munkstrup, Charlotte

AU - Edslev, Sofie Marie

AU - Baig, Sharmin

AU - Nielsen, Stine

AU - Funk, Tjede

AU - Kristensen, Dennis Karsten

AU - Jacobsen, Lars Hervig

AU - Ravn, Signe Fischer

AU - Bindslev, Niels

AU - Gubbels, Sophie

AU - Voldstedlund, Marianne

AU - Jokelainen, Pikka

AU - Hallstrøm, Søren

AU - Rasmussen, Astrid

AU - Kristinsson, Karl Gústaf

AU - Fuglsang-Damgaard, David

AU - Dessau, Ram B

AU - Olsén, Agnieszka Barbara

AU - Jensen, Christian Salgaard

AU - Skovby, Annette

AU - Ellermann-Eriksen, Svend

AU - Jensen, Thøger Gorm

AU - Dzajic, Esad

AU - Østergaard, Claus

AU - Lomborg Andersen, Steen

AU - Hoffmann, Steen

AU - Andersen, Peter Henrik

AU - Stegger, Marc

PY - 2023/6

Y1 - 2023/6

N2 - A highly virulent sub-lineage of the Streptococcus pyogenes M1 clone has been rapidly expanding throughout Denmark since late 2022 and now accounts for 30% of the new invasive group A streptococcal infections. We aimed to investigate whether a shift in variant composition can account for the high incidence rates observed over winter 2022/23, or if these are better explained by the impact of COVID-19-related restrictions on population immunity and carriage of group A Streptococcus.

AB - A highly virulent sub-lineage of the Streptococcus pyogenes M1 clone has been rapidly expanding throughout Denmark since late 2022 and now accounts for 30% of the new invasive group A streptococcal infections. We aimed to investigate whether a shift in variant composition can account for the high incidence rates observed over winter 2022/23, or if these are better explained by the impact of COVID-19-related restrictions on population immunity and carriage of group A Streptococcus.

KW - Humans

KW - COVID-19

KW - Streptococcus pyogenes/genetics

KW - Seasons

KW - Streptococcal Infections/epidemiology

KW - Denmark/epidemiology

U2 - 10.2807/1560-7917.ES.2023.28.26.2300291

DO - 10.2807/1560-7917.ES.2023.28.26.2300291

M3 - Article

C2 - 37382884

SN - 1560-7917

VL - 28

JO - Eurosurveillance

JF - Eurosurveillance

IS - 26

ER -

Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 clone, Denmark, 2023

Abstract

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