TY - JOUR
T1 - Incidence and Survival of Colorectal Cancer in the United Kingdom From 2000 to 2021
T2 - a population-based cohort study
AU - Pedregal-Pascual, Patricia
AU - Guarner-Argente, Carlos
AU - Tan, Eng Hooi
AU - Golozar, Asieh
AU - Duarte-Salles, Talita
AU - Rosen, Andreas Weinberger
AU - Delmestri, Antonella
AU - Man, Wai Yi
AU - Burn, Edward
AU - Prieto-Alhambra, Daniel
AU - Newby, Danielle
N1 - Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.
PY - 2025/12/1
Y1 - 2025/12/1
N2 - INTRODUCTION: The management of colorectal cancer (CRC) is evolving, with advances in screening and treatment. The purpose of this study was to leverage population-based data to generate up-to-date UK estimates of age-specific and sex-specific incidence and overall survival for the period 2000-2021.METHODS: We analyzed nationally representative primary care records from Clinical Practice Research Datalink GOLD and replicated in Clinical Practice Research Datalink Aurum. We calculated incidence rates, and short-term and long-term survival stratified by age, sex, and diagnosis year.RESULTS: Overall incidence was 67.4/100,000 person years, increasing in 2000-2011 to drop slightly in 2011-2014, and then plateauing. By contrast, early-onset CRC raised uninterruptedly throughout the study period, from 8.33 to 19.07/100,000 person-years. Overall survival was 78.3%, 51.4%, and 38.5% at 1, 5, and 10 years, respectively, lower in men compared with women. Modest improvements in survival were observed over the study period, particularly for 60-69-year-old patients.DISCUSSION: Although the overall incidence in the population has plateaued, a worrying increasing trend of early-onset CRC was observed. Moreover, the slight improvement in overall survival suggests that significant progress is still needed. These findings highlight the urgent need for continued research and resource allocation to improve the diagnosis and management of CRC.
AB - INTRODUCTION: The management of colorectal cancer (CRC) is evolving, with advances in screening and treatment. The purpose of this study was to leverage population-based data to generate up-to-date UK estimates of age-specific and sex-specific incidence and overall survival for the period 2000-2021.METHODS: We analyzed nationally representative primary care records from Clinical Practice Research Datalink GOLD and replicated in Clinical Practice Research Datalink Aurum. We calculated incidence rates, and short-term and long-term survival stratified by age, sex, and diagnosis year.RESULTS: Overall incidence was 67.4/100,000 person years, increasing in 2000-2011 to drop slightly in 2011-2014, and then plateauing. By contrast, early-onset CRC raised uninterruptedly throughout the study period, from 8.33 to 19.07/100,000 person-years. Overall survival was 78.3%, 51.4%, and 38.5% at 1, 5, and 10 years, respectively, lower in men compared with women. Modest improvements in survival were observed over the study period, particularly for 60-69-year-old patients.DISCUSSION: Although the overall incidence in the population has plateaued, a worrying increasing trend of early-onset CRC was observed. Moreover, the slight improvement in overall survival suggests that significant progress is still needed. These findings highlight the urgent need for continued research and resource allocation to improve the diagnosis and management of CRC.
KW - Humans
KW - Colorectal Neoplasms/epidemiology
KW - Female
KW - Male
KW - United Kingdom/epidemiology
KW - Incidence
KW - Middle Aged
KW - Aged
KW - Adult
KW - Survival Rate
KW - Cohort Studies
KW - Aged, 80 and over
KW - Colorectal cancer
KW - Cancer survival
KW - Population-based study
U2 - 10.14309/ajg.0000000000003460
DO - 10.14309/ajg.0000000000003460
M3 - Article
C2 - 40167184
SN - 0002-9270
VL - 120
SP - 2909
EP - 2917
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 12
ER -