TY - JOUR
T1 - In vivo measurement of intracellular pH in human brain during different tensions of carbon dioxide in arterial blood. A 31P‐NMR study
AU - Jensen, K. E.
AU - Thomsen, C.
AU - Henriksen, O.
PY - 1988/10
Y1 - 1988/10
N2 - The effect of changes in carbon dioxide tension in arterial blood upon intracellular pH in brain tissue was studied in seven healthy volunteers, aged 22–45 years. The pH changes were monitored by use of 31P nuclear magnetic resonance spectroscopy, performed on a whole‐body 1.5 Tesla Siemens imaging system. The measurements were carried out during hyperventilation and with the subject breathing atmospheric air containing 5 vol. % and 7 vol. % carbon dioxide. Intracellular pH increased significantly during 15 min of hyper‐ventilation and decreased significantly during 18 min respiration of air containing 7 vol. %, carbon dioxide. The intracellular buffer capacity was estimated. These results suggest that the ventilation response to carbon dioxide is correlated to changes in intracellular fluid pH.
AB - The effect of changes in carbon dioxide tension in arterial blood upon intracellular pH in brain tissue was studied in seven healthy volunteers, aged 22–45 years. The pH changes were monitored by use of 31P nuclear magnetic resonance spectroscopy, performed on a whole‐body 1.5 Tesla Siemens imaging system. The measurements were carried out during hyperventilation and with the subject breathing atmospheric air containing 5 vol. % and 7 vol. % carbon dioxide. Intracellular pH increased significantly during 15 min of hyper‐ventilation and decreased significantly during 18 min respiration of air containing 7 vol. %, carbon dioxide. The intracellular buffer capacity was estimated. These results suggest that the ventilation response to carbon dioxide is correlated to changes in intracellular fluid pH.
KW - intracellular brain pH
KW - intracellular buffer capacity
KW - respiration regulation
KW - [P] nuclear magnetic resonance spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=0023713819&partnerID=8YFLogxK
U2 - 10.1111/j.1748-1716.1988.tb08492.x
DO - 10.1111/j.1748-1716.1988.tb08492.x
M3 - Article
C2 - 3147578
AN - SCOPUS:0023713819
SN - 0001-6772
VL - 134
SP - 295
EP - 298
JO - Acta Physiologica Scandinavica
JF - Acta Physiologica Scandinavica
IS - 2
ER -