Improved Survival Among Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Treated With Remdesivir and Dexamethasone: A nationwide population-based cohort study

Thomas Benfield, Jacob Bodilsen, Christian Brieghel, Zitta Barrella Harboe, Marie Helleberg, Claire Holm, Simone Bastrup Israelsen, Janne Jensen, Tomas Østergaard Jensen, Isik Somuncu Johansen, Stine Johnsen, Birgitte Lindegaard Madsen, Jens Lundgren, Christian Niels Meyer, Rajesh Mohey, Lars Møller Pedersen, Henrik Nielsen, Stig Lønberg Nielsen, Niels Obel, Lars Haukali OmlandDaria Podlekareva, Birgitte Klindt Poulsen, Pernille Ravn, Haakon Sandholdt, Jonathan Starling, Merete Storgaard, Christian Søborg, Ole Schmeltz Søgaard, Torben Tranborg, Lothar Wiese, Hanne Rolighed Christensen

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Abstrakt

BACKGROUND: There is limited data on outcomes of moderate to severe Coronavirus disease 2019 (COVID-19) among patients treated with remdesivir and dexamethasone in a real-world setting.

OBJECTIVE: To compare the effectiveness of standard of care (SOC) alone vs SOC plus remdesivir and dexamethasone.

METHODS: Two population-based nationwide cohorts of individuals hospitalized with COVID-19 during February through December 2020. Death within 30 days and need of mechanical ventilation (MV) were compared by inverse probability of treatment weighted (ITPW) logistic regression analysis and shown as odds ratio (OR) with 95% confidence interval (CI).

RESULTS: The 30-d mortality rate of 1694 individuals treated with remdesivir and dexamethasone in addition to SOC was 12.6% compared to 19.7% for 1053 individuals receiving SOC alone. This corresponded to a weighted OR of 30-day mortality of 0.47 (95% CI, 0.38-0.57) for patients treated with remdesivir and dexamethasone compared to patients receiving SOC alone. Similarly, progression to MV was reduced (OR 0.36 (95% CI, 0.29-0.46)).

CONCLUSIONS AND RELEVANCE: Treatment of moderate to severe COVID-19 during June through December that included remdesivir and dexamethasone was associated with reduced 30-day mortality and need of MV compared to treatment in February through May.

OriginalsprogEngelsk
TidsskriftClinical infectious diseases : an official publication of the Infectious Diseases Society of America
DOI
StatusUdgivet, E-publikation før trykning - 10 jun. 2021

Bibliografisk note

© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

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