Improved energy kinetics following high protein diet in McArdle's syndrome. A ³¹P magnetic resonance spectroscopy study

A patient with McArdle's syndrome was examined using bicycle ergometry and ³¹P NMR spectroscopy during exercise. The patients working capacity was approximately half the expected capacity of controls. Muscle energy kinetics improved significantly during intravenous glucose infusion and after 6 weeks of high protein diet. During intravenous infusion of amino acids, no changes in working capacity could be detected. No decrease was seen in intracellular muscle pH during aerobic exercise. A significant decrease in muscle pH during aerobic exercise was detected in all controls.