Abstract
INTRODUCTION: Patients with chronic pain after laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery frequently report intense postprandial abdominal pain. Reduced blood supply due to atherosclerosis was hypothesised to be a contributing cause.
METHODS: This was a retrospective, single-centre cohort study including all patients with LRYGB surgery from 2010 through 2015. Data from multiple registries, medical records and a questionnaire were used. The risk of chronic abdominal pain was analysed using multivariate logistic regression.
RESULTS: We included 787 patients. Among these, 177 (23%) patients were defined as having chronic abdominal pain. The median follow-up was 63 months. When investigating the impact of risk factors for atherosclerosis including dyslipidaemia, Type 2 diabetes, hypertension, smoking and cardiovascular co-morbidities, the "atherosclerosis composite score" was a significant risk factor (odds ratio = 1.22, 95% confidence interval: 1.02-1.45). In a multivariate model specifically investigating dyslipidaemia, the association with chronic abdominal pain was non-significant.
CONCLUSIONS: In this exploratory study, development of chronic abdominal pain was significantly associated with risk factors for atherosclerosis, but the specific association with dyslipidaemia was non-significant.
FUNDING: The study was supported by the Danish Medical Association's Research Foundation and the Edgar Schnohr Foundation.
TRIAL REGISTRATION: The study was approved by the Danish Data Protection Agency (No. REG-063-2017).
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | A05200330 |
| Antal sider | 10 |
| Tidsskrift | Danish medical journal |
| Vol/bind | 67 |
| Udgave nummer | 11 |
| Status | Udgivet - 29 okt. 2020 |