IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis

Simon Jønck; Malte Lund Adamsen; Iben E Rasmussen; Anna A Lytzen; Mathilde Løk; Morten Asp Vonsild Lund; Lene Wohlfahrt Dreyer; Peter G Jørgensen; Niels Vejlstrup; Lars Køber; Robin Christensen; Søren Jacobsen; Bente Klarlund Pedersen; Helga Ellingsgaard; Pil Højgaard; Ronan M G Berg; Regitse Højgaard Christensen

doi:10.1016/j.jacbts.2024.11.010

IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis

Simon Jønck^*
, Malte Lund Adamsen
, Iben E Rasmussen
, Anna A Lytzen
, Mathilde Løk
, Morten Asp Vonsild Lund
, Lene Wohlfahrt Dreyer
, Peter G Jørgensen
, Niels Vejlstrup
, Lars Køber
, Robin Christensen
, Søren Jacobsen
, Bente Klarlund Pedersen
, Helga Ellingsgaard
, Pil Højgaard
, Ronan M G Berg
, Regitse Højgaard Christensen

^*Corresponding author af dette arbejde

Medicin 2

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

Interleukin-6 inhibitors (IL-6i) are commonly used in patients with rheumatoid arthritis to reduce inflammation from chronically increased IL-6. IL-6 levels increase transiently following exercise, exerting numerous positive effects. This study examined if beneficial exercise-induced cardiac adaptations were attenuated in patients with rheumatoid arthritis in concomitant IL-6i treatment compared with tumor necrosis factor inhibitors. Compared with control, we found that the tumor necrosis factor inhibitor-treated group, but not the IL-6i group, had a significant increase in left ventricular mass following 12 weeks of supervised exercise. However, the interaction effect of treatment modalities on exercise-induced cardiac adaptations was insignificant. (Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During IL-6 vs TNF Antibody Therapy; NCT05215509).

Originalsprog	Engelsk
Sider (fra-til)	551-563
Antal sider	13
Tidsskrift	JACC: Basic to Translational Science
Vol/bind	10
Udgave nummer	5
DOI	https://doi.org/10.1016/j.jacbts.2024.11.010
Status	Udgivet - maj 2025

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10.1016/j.jacbts.2024.11.010

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Jønck, S., Adamsen, M. L., Rasmussen, I. E., Lytzen, A. A., Løk, M., Vonsild Lund, M. A., Dreyer, L. W., Jørgensen, P. G., Vejlstrup, N., Køber, L., Christensen, R., Jacobsen, S., Pedersen, B. K., Ellingsgaard, H., Højgaard, P., Berg, R. M. G., & Christensen, R. H. (2025). IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis. JACC: Basic to Translational Science, 10(5), 551-563. https://doi.org/10.1016/j.jacbts.2024.11.010

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title = "IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis",

abstract = "Interleukin-6 inhibitors (IL-6i) are commonly used in patients with rheumatoid arthritis to reduce inflammation from chronically increased IL-6. IL-6 levels increase transiently following exercise, exerting numerous positive effects. This study examined if beneficial exercise-induced cardiac adaptations were attenuated in patients with rheumatoid arthritis in concomitant IL-6i treatment compared with tumor necrosis factor inhibitors. Compared with control, we found that the tumor necrosis factor inhibitor-treated group, but not the IL-6i group, had a significant increase in left ventricular mass following 12 weeks of supervised exercise. However, the interaction effect of treatment modalities on exercise-induced cardiac adaptations was insignificant. (Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During IL-6 vs TNF Antibody Therapy; NCT05215509).",

keywords = "Cardiac adaptations, Exercise, Interleukin-6, Rheumatoid arthritis",

author = "Simon J{\o}nck and Adamsen, \{Malte Lund\} and Rasmussen, \{Iben E\} and Lytzen, \{Anna A\} and Mathilde L{\o}k and \{Vonsild Lund\}, \{Morten Asp\} and Dreyer, \{Lene Wohlfahrt\} and J{\o}rgensen, \{Peter G\} and Niels Vejlstrup and Lars K{\o}ber and Robin Christensen and S{\o}ren Jacobsen and Pedersen, \{Bente Klarlund\} and Helga Ellingsgaard and Pil H{\o}jgaard and Berg, \{Ronan M G\} and Christensen, \{Regitse H{\o}jgaard\}",

year = "2025",

month = may,

doi = "10.1016/j.jacbts.2024.11.010",

language = "English",

volume = "10",

pages = "551--563",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

publisher = "Elsevier",

number = "5",

}

Jønck, S, Adamsen, ML, Rasmussen, IE, Lytzen, AA, Løk, M, Vonsild Lund, MA, Dreyer, LW, Jørgensen, PG, Vejlstrup, N, Køber, L, Christensen, R, Jacobsen, S, Pedersen, BK, Ellingsgaard, H, Højgaard, P, Berg, RMG & Christensen, RH 2025, 'IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis', JACC: Basic to Translational Science, bind 10, nr. 5, s. 551-563. https://doi.org/10.1016/j.jacbts.2024.11.010

TY - JOUR

T1 - IL-6 Inhibitors and TNF Inhibitors

T2 - Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis

AU - Jønck, Simon

AU - Adamsen, Malte Lund

AU - Rasmussen, Iben E

AU - Lytzen, Anna A

AU - Løk, Mathilde

AU - Vonsild Lund, Morten Asp

AU - Dreyer, Lene Wohlfahrt

AU - Jørgensen, Peter G

AU - Vejlstrup, Niels

AU - Køber, Lars

AU - Christensen, Robin

AU - Jacobsen, Søren

AU - Pedersen, Bente Klarlund

AU - Ellingsgaard, Helga

AU - Højgaard, Pil

AU - Berg, Ronan M G

AU - Christensen, Regitse Højgaard

PY - 2025/5

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N2 - Interleukin-6 inhibitors (IL-6i) are commonly used in patients with rheumatoid arthritis to reduce inflammation from chronically increased IL-6. IL-6 levels increase transiently following exercise, exerting numerous positive effects. This study examined if beneficial exercise-induced cardiac adaptations were attenuated in patients with rheumatoid arthritis in concomitant IL-6i treatment compared with tumor necrosis factor inhibitors. Compared with control, we found that the tumor necrosis factor inhibitor-treated group, but not the IL-6i group, had a significant increase in left ventricular mass following 12 weeks of supervised exercise. However, the interaction effect of treatment modalities on exercise-induced cardiac adaptations was insignificant. (Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During IL-6 vs TNF Antibody Therapy; NCT05215509).

AB - Interleukin-6 inhibitors (IL-6i) are commonly used in patients with rheumatoid arthritis to reduce inflammation from chronically increased IL-6. IL-6 levels increase transiently following exercise, exerting numerous positive effects. This study examined if beneficial exercise-induced cardiac adaptations were attenuated in patients with rheumatoid arthritis in concomitant IL-6i treatment compared with tumor necrosis factor inhibitors. Compared with control, we found that the tumor necrosis factor inhibitor-treated group, but not the IL-6i group, had a significant increase in left ventricular mass following 12 weeks of supervised exercise. However, the interaction effect of treatment modalities on exercise-induced cardiac adaptations was insignificant. (Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During IL-6 vs TNF Antibody Therapy; NCT05215509).

KW - Cardiac adaptations

KW - Exercise

KW - Interleukin-6

KW - Rheumatoid arthritis

U2 - 10.1016/j.jacbts.2024.11.010

DO - 10.1016/j.jacbts.2024.11.010

M3 - Article

C2 - 40436519

SN - 2452-302X

VL - 10

SP - 551

EP - 563

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 5

ER -

IL-6 Inhibitors and TNF Inhibitors: Impact on Exercise-induced Cardiac Adaptations in Patients With Rheumatoid Arthritis

Abstract

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