Hypothalamus-hypophysis-adrenal-cortical function in chronic alcoholism

J. Selmer, H. Hasselbalch, L. Sestoft, H. Kehlet

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    Hypothalamic-pituitary-adrenocortical (HPA) function was assessed during normal daily work and family life in 15 male brewery workers with a daily alcohol intake of 100 g or more for at least 10 years. Free urinary cortisol was determined during 3 baseline days and for 3 days during administration of dexamethasone 0.5 mg 6-hourly. All subjects had normal basal urinary cortisol excretion and all, except one, suppressed normally upon dexamethasone. 4 subjects had cushingoid-like moon face and 2 of these also buffalo hump. There was no correlation between free urinary cortisol excretion of dexamethasone suppression and the cushingoid stigmata. It is concluded that chronic alcohol intake per se does not influence HPA-function. Previous reports of biochemical evidence of HPA hyperfunction together with cushingoid appearance in chronic alcoholics are probably explained by factors other than alcohol as such, leading to increased HPA function.

    OriginalsprogEngelsk
    Sider (fra-til)937-939
    Antal sider3
    TidsskriftUgeskrift for laeger
    Vol/bind144
    Udgave nummer13
    StatusUdgivet - 1 jan. 1982

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Hypothalamus-hypophysis-adrenal-cortical function in chronic alcoholism' indeholder.

    Citationsformater