Hypercalcemia in idiopathic myelofibrosis: Modulation of calcium and collagen homeostasis by 1,25‐dihydroxyvitamin D3

A. Voss, K. Schmidt, H. Hasselbalch, P. Junker

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    Abstrakt

    A case of idiopathic myelofibrosis (IMF) presenting with hypercalcemia and hypercalcitriolemia is reported. It is proposed that ectopic production of the active vitamin D metabolite related to ongoing clonal expansion in the bone marrow accounts for the hypercalcemic state. Consistently low levels of circulating type I procollagen propeptide (PICP) and lack of progression of the bone marrow fibrosis during almost 6 months of follow‐up point to an in vivo inhibition of type I collagen synthesis by 1,25‐dihydroxyvitamin D3.

    OriginalsprogEngelsk
    Sider (fra-til)231-233
    Antal sider3
    TidsskriftAmerican Journal of Hematology
    Vol/bind39
    Udgave nummer3
    DOI
    StatusUdgivet - mar. 1992

    Fingeraftryk Udforsk hvilke forskningsemner 'Hypercalcemia in idiopathic myelofibrosis: Modulation of calcium and collagen homeostasis by 1,25‐dihydroxyvitamin D3' indeholder.

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