Hypercalcaemia in the accelerated phase of chronic myelogenous leukaemia: No relationship to the phenotype of the blast cells

H. Hasselbalch*, H. S. Birgens, C. Geisler, N. E. Hansen

*Corresponding author af dette arbejde

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    Abstrakt

    2 patients with chronic myelogenous leukaemia developed hypercalcaemia and severe myelofibrosis in the terminal phases of their disease. Hormonal studies excluded the hypercalcaemia being caused by primary hyperparathyroidism or ectopic parathyroid hormone secretion. Its development was unrelated to the phenotype of the blast cells, as assessed by conventional cytochemistry and immunological surface typing. The finding of increased urinary cAMP excretion in 1 of the patients suggests a circulating, nonparathyroid humoral bone resorbing factor with partial biological PTH‐activity to be one of the pathogenetic mechanisms responsible for the occurrence of hypercalcaemia in patients with chronic myelogenous leukaemia.

    OriginalsprogEngelsk
    Sider (fra-til)333-338
    Antal sider6
    TidsskriftScandinavian Journal of Haematology
    Vol/bind35
    Udgave nummer3
    DOI
    StatusUdgivet - sep. 1985

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Hypercalcaemia in the accelerated phase of chronic myelogenous leukaemia: No relationship to the phenotype of the blast cells' indeholder.

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