Hormoonsuppletie en fertiliteit bij het syndroom van Turner

N. S. Macklon*, D. D.M. Braat

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

    Abstract

    Women with Turner Syndrome (TS) are frequently given hormone replacement therapy (HRT), in the first place to induce breast development, later to prevent dyspareunia (related to vaginal dryness). HRT has also beneficial effects on bone density and hyperinsulinism. Although spontaneous pregnancies may occur in 3-5% of women with TS, most are faced with the prospect and sequelae of premature ovarian failure. The availability of oocyte donation combined with in-vitro fertilization now offers these women a realistic chance of conceiving and delivering a healthy child. While recent case series indicate that conception rates rival those obtained in non-Turners women, the pregnancies are more frequently complicated by miscarriage and the need for caesarean section. Pregnancy in is associated with maternal morbidity. Those with cardiovascular abnormalities may be at risk of aortic dissection and pre-pregnancy screening is therefore recommended.

    Bidragets oversatte titelHormone replacement therapy and fertility in Turner's syndrome
    OriginalsprogNederlandsk
    Sider (fra-til)107-110
    Antal sider4
    TidsskriftTijdschrift voor Kindergeneeskunde
    Vol/bind70
    Udgave nummer3
    StatusUdgivet - 1 jan. 2002

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