High-sensitivity C-reactive protein is only weakly related to cardiovascular damage after adjustment for traditional cardiovascular risk factors

Michael H. Olsen*, Marina K. Christensen, Tine W. Hansen, Finn Gustafsson, Susanne Rasmussen, Kristian Wachtell, Knut Borch-Johnsen, Hans Ibsen, Torben Jørgensen, Per Hildebrandt

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review


    Background: The independent prognostic value of high-sensitivity C-reactive protein (hsCRP) has been questioned, and consequently we decided to investigate whether hsCRP was associated with subclinical cardiovascular (CV) damage independently of traditional CV risk factors. Methods: In a population-based sample of 2028 apparently healthy individuals without prior stroke or myocardial infarction not receiving any CV, anti-diabetic or lipid-lowering treatment, aged 41, 51, 61 or 71 years, we measured in 1993 serum hsCRP, traditional CV risk factors (lifestyle, metabolic and hemodynamic) and assessed subclinical CV damage [atherosclerotic plaques in the carotid arteries, pulse wave velocity (PWV), urine albumin/creatinine ratio (UACR), left ventricular (LV) mass and ejection fraction]. Results: Adjusting for age and gender in multiple regression analyses, higher log(hsCRP) was associated with higher logPWV (β = 0.15) and log(left ventricular mass index) (LVMI) (β = 0.09, both P < 0.001), LV relative wall thickness (β = 0.07, P < 0.01), logUACR (β = 0.04, P = 0.06) and more atherosclerotic plaques (β = 0.06, P < 0.05). However, higher log(hsCRP) was only weakly associated with higher logPWV(β = 0.06, P < 0.05) and more atherosclerotic plaques (β = 0.04, P = 0.06) when adjusting for other significant CV risk factors, such as daily smoking (β = 0.18), female gender (β = -0.17), older age (β = 0.11), lower log(high density lipoprotein cholesterol) (β = -0.11, all P < 0.001); wider waist (β = 0.17), higher body mass index (β = 0.14), higher heart rate (β = 0.06, all P < 0.01); and higher logiplasma glucose) (β = 0.05, P < 0.05) (adj. R 2 = 0.19, P < 0.001). Conclusion: After adjustment for traditional CV risk factors hsCRP was only associated with PWV and atherosclerotic plaques, indicating a possible effect of low-grade inflammation on macrovascular damage. The close relationship between traditional CV risk factors and hsCRP suggested that hsCRP was an integrated CV risk marker early in the development of atherosclerosis.

    Sider (fra-til)655-661
    Antal sider7
    TidsskriftJournal of Hypertension
    Udgave nummer4
    StatusUdgivet - 1 apr. 2006


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