TY - JOUR
T1 - High frequency spectral changes induced by single-pulse electric stimulation
T2 - Comparison between physiologic and pathologic networks
AU - Mălîia, Mihai Dragos
AU - Donos, Cristian
AU - Barborica, Andrei
AU - Mindruta, Ioana
AU - Popa, Irina
AU - Ene, Mirela
AU - Beniczky, Sándor
N1 - Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
PY - 2017/6
Y1 - 2017/6
N2 - OBJECTIVE: To investigate functional coupling between brain networks using spectral changes induced by single-pulse electric stimulation (SPES).METHOD: We analyzed 20 patients with focal epilepsy, implanted with depth electrodes. SPES was applied to each pair of adjacent contacts, and responses were recorded from all other contacts. The mean response amplitude value was quantified in three time-periods after stimulation (10-60, 60-255, 255-500ms) for three frequency-ranges (Gamma, Ripples, Fast-Ripples), and compared to baseline. A total of 30,755 responses were analyzed, taking into consideration three dichotomous pairs: stimulating in primary sensory areas (S1-V1) vs. outside them, to test the interaction in physiologic networks; stimulating in seizure onset zone (SOZ) vs. non-SOZ, to test pathologic interactions; recording in default mode network (DMN) vs. non-DMN.RESULTS: Overall, we observed an early excitation (10-60ms) and a delayed inhibition (60-500ms). More specifically, in the delayed period, stimulation in S1-V1 produced a higher gamma-inhibition in the DMN, while stimulation in the SOZ induced a higher inhibition in the epilepsy-related higher frequencies (Ripples and Fast-Ripples).CONCLUSION: Physiologic and pathologic interactions can be assessed using spectral changes induced by SPES.SIGNIFICANCE: This is a promising method for connectivity studies in patients with drug-resistant focal epilepsy.
AB - OBJECTIVE: To investigate functional coupling between brain networks using spectral changes induced by single-pulse electric stimulation (SPES).METHOD: We analyzed 20 patients with focal epilepsy, implanted with depth electrodes. SPES was applied to each pair of adjacent contacts, and responses were recorded from all other contacts. The mean response amplitude value was quantified in three time-periods after stimulation (10-60, 60-255, 255-500ms) for three frequency-ranges (Gamma, Ripples, Fast-Ripples), and compared to baseline. A total of 30,755 responses were analyzed, taking into consideration three dichotomous pairs: stimulating in primary sensory areas (S1-V1) vs. outside them, to test the interaction in physiologic networks; stimulating in seizure onset zone (SOZ) vs. non-SOZ, to test pathologic interactions; recording in default mode network (DMN) vs. non-DMN.RESULTS: Overall, we observed an early excitation (10-60ms) and a delayed inhibition (60-500ms). More specifically, in the delayed period, stimulation in S1-V1 produced a higher gamma-inhibition in the DMN, while stimulation in the SOZ induced a higher inhibition in the epilepsy-related higher frequencies (Ripples and Fast-Ripples).CONCLUSION: Physiologic and pathologic interactions can be assessed using spectral changes induced by SPES.SIGNIFICANCE: This is a promising method for connectivity studies in patients with drug-resistant focal epilepsy.
KW - Adolescent
KW - Adult
KW - Case-Control Studies
KW - Child
KW - Deep Brain Stimulation
KW - Epilepsies, Partial/physiopathology
KW - Evoked Potentials
KW - Female
KW - Gamma Rhythm
KW - Humans
KW - Male
KW - Middle Aged
KW - Somatosensory Cortex/physiology
U2 - 10.1016/j.clinph.2016.12.016
DO - 10.1016/j.clinph.2016.12.016
M3 - Article
C2 - 28131532
VL - 128
SP - 1053
EP - 1060
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 6
ER -