High frequency spectral changes induced by single-pulse electric stimulation: Comparison between physiologic and pathologic networks

Mihai Dragos Mălîia, Cristian Donos, Andrei Barborica, Ioana Mindruta, Irina Popa, Mirela Ene, Sándor Beniczky*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

OBJECTIVE: To investigate functional coupling between brain networks using spectral changes induced by single-pulse electric stimulation (SPES).

METHOD: We analyzed 20 patients with focal epilepsy, implanted with depth electrodes. SPES was applied to each pair of adjacent contacts, and responses were recorded from all other contacts. The mean response amplitude value was quantified in three time-periods after stimulation (10-60, 60-255, 255-500ms) for three frequency-ranges (Gamma, Ripples, Fast-Ripples), and compared to baseline. A total of 30,755 responses were analyzed, taking into consideration three dichotomous pairs: stimulating in primary sensory areas (S1-V1) vs. outside them, to test the interaction in physiologic networks; stimulating in seizure onset zone (SOZ) vs. non-SOZ, to test pathologic interactions; recording in default mode network (DMN) vs. non-DMN.

RESULTS: Overall, we observed an early excitation (10-60ms) and a delayed inhibition (60-500ms). More specifically, in the delayed period, stimulation in S1-V1 produced a higher gamma-inhibition in the DMN, while stimulation in the SOZ induced a higher inhibition in the epilepsy-related higher frequencies (Ripples and Fast-Ripples).

CONCLUSION: Physiologic and pathologic interactions can be assessed using spectral changes induced by SPES.

SIGNIFICANCE: This is a promising method for connectivity studies in patients with drug-resistant focal epilepsy.

OriginalsprogEngelsk
Sider (fra-til)1053-1060
Antal sider8
TidsskriftClinical Neurophysiology
Vol/bind128
Udgave nummer6
DOI
StatusUdgivet - jun. 2017

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