Health-related quality of life in adult dermatitis patients stratified by filaggrin genotype

Nina G. Heede*, Jacob P. Thyssen, Betina H. Thuesen, Allan Linneberg, Pal B. Szecsi, Steen Stender, Jeanne D. Johansen

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review


    Background: Information concerning health-related quality of life (HRQoL) and comorbidities of adult dermatitis patients stratified by loss-of-function mutations in the filaggrin gene (FLG) is limited. Objective: To investigate HRQoL, skin symptoms and comorbidities in adult FLG mutation carriers. Methods: This cross-sectional study included patients diagnosed with atopic dermatitis and/or hand eczema (n = 520). Patients completed questionnaires about dermatitis, skin symptoms, HRQoL, and comorbidities, including actinic keratosis, and atopic and mental disorders. Results: FLG mutations (R501X, 2282del4, and R2447X) were identified in 16.9% of patients, and were significantly associated not only with atopic dermatitis, but also independently with skin fissures on the fingers and heels, and self-reported actinic keratosis. Although FLG mutations were significantly associated with reduced HRQoL, as measured by use of the Dermatology Life Quality Index (DLQI), no association with self-reported anxiety or depression was identified. Notably, the highest median DLQI score, reflecting greater impairment, was reported by patients with both FLG mutations and atopic dermatitis. Overall, 19.7% of patients with both atopic dermatitis and FLG mutations reported a ‘large or extremely large’ impact on their lives; this represents twice the prevalence seen in patients with atopic dermatitis and wild-type FLG (9.6%). Conclusion: Patients with both atopic dermatitis and common FLG mutations are more frequently affected by reduced HRQoL.

    Sider (fra-til)167-177
    Antal sider11
    TidsskriftContact Dermatitis
    Udgave nummer3
    StatusUdgivet - 1 mar. 2017


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