TY - JOUR
T1 - Health-Related Quality of Life, Dysphagia, Voice Problems, Depression, and Anxiety After Total Laryngectomy
AU - Wulff, Nille B
AU - Dalton, Susanne O
AU - Wessel, Irene
AU - Arenaz Búa, Beatriz
AU - Löfhede, Helena
AU - Hammerlid, Eva
AU - Kjaer, Trille K
AU - Godballe, Christian
AU - Kjaergaard, Thomas
AU - Homøe, Preben
N1 - © 2021 The American Laryngological, Rhinological and Otological Society, Inc.
PY - 2022/5
Y1 - 2022/5
N2 - OBJECTIVES/HYPOTHESIS: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects.STUDY DESIGN: Cross-sectional study.METHODS: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires.RESULTS: Participants scored worse than normative reference populations on all scales/items of the EORTC questionnaires, except one, and almost half of the scales/items showed a clinically relevant difference. Moderate/severe dysphagia was present in 46%, moderate/severe voice problems in 57%, depression in 16%, and anxiety in 20%. Decreasing age, increasing numbers of comorbidities, increasing voice problems, increasing dysphagia, and increasing depression symptoms, were associated with a lowered EORTC QLQ-C30 summary score.CONCLUSION: A substantial proportion of participants experienced clinically significant late effects and increasing levels of these were associated with a lowered HRQoL.LEVEL OF EVIDENCE: 3 Laryngoscope, 132:980-988, 2022.
AB - OBJECTIVES/HYPOTHESIS: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects.STUDY DESIGN: Cross-sectional study.METHODS: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires.RESULTS: Participants scored worse than normative reference populations on all scales/items of the EORTC questionnaires, except one, and almost half of the scales/items showed a clinically relevant difference. Moderate/severe dysphagia was present in 46%, moderate/severe voice problems in 57%, depression in 16%, and anxiety in 20%. Decreasing age, increasing numbers of comorbidities, increasing voice problems, increasing dysphagia, and increasing depression symptoms, were associated with a lowered EORTC QLQ-C30 summary score.CONCLUSION: A substantial proportion of participants experienced clinically significant late effects and increasing levels of these were associated with a lowered HRQoL.LEVEL OF EVIDENCE: 3 Laryngoscope, 132:980-988, 2022.
KW - Anxiety/epidemiology
KW - Cross-Sectional Studies
KW - Deglutition Disorders/epidemiology
KW - Depression/epidemiology
KW - Humans
KW - Laryngeal Neoplasms/surgery
KW - Laryngectomy/adverse effects
KW - Quality of Life
KW - Surveys and Questionnaires
KW - Voice Disorders
U2 - 10.1002/lary.29857
DO - 10.1002/lary.29857
M3 - Article
C2 - 34490903
SN - 0023-852X
VL - 132
SP - 980
EP - 988
JO - Laryngoscope
JF - Laryngoscope
IS - 5
ER -