Haemostatic variables in Pacific Islanders apparently free from stroke and ischaemic heart disease - The Kitava study

Staffan Lindeberg*, Erik Berntorp, Roland Carlsson, Mats Eliasson, Peter Marckmann

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    We cross-sectionally measured plasminogen activator inhibitor-1 (PAI-1) activity, fibrinogen, factor VII(FVII:C) and VIII (FVIII:C) coagulant activity, and von Willebrand factor antigen (VWF:Ag) in 162 traditional horticulturalists older than 40 years from the tropical island of Kitava, Papua New Guinea, where the intake of western food is negligible and where stroke and ischaemic heart disease appear to be absent. Identical analyses were made in Swedish subjects of comparable ages. Kitavans had markedly lower PAI-1 activity, with 85% of males and 100% of females having PAI-1 activity ≤ 5 U/ml, as compared with 22 and 14% in Swedish males and females (p < 0.0001). Surprisingly, Kitavans also had higher FVII:C, FVIII:C and VWF:Ag. Fibrinogen was 10% lower in Kitavan males while 25% higher in Kitavan females. The very low PAI-1 activity in Kitavans may explain some of their apparent freedom from cardiovascular disease and probably relates to their extreme leanness.

    OriginalsprogEngelsk
    Sider (fra-til)94-98
    Antal sider5
    TidsskriftThrombosis and Haemostasis
    Vol/bind77
    Udgave nummer1
    StatusUdgivet - 1 jan. 1997

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Haemostatic variables in Pacific Islanders apparently free from stroke and ischaemic heart disease - The Kitava study' indeholder.

    Citationsformater