Gut microbiota and depressive symptoms

Julie Kristine Knudsen, Zenia Funch Jensen, Alice Højer Christensen, Stig Günther, Lene Nørby Nielsen, Peter Deutscher, Sidse Arnfred

Publikation: Bidrag til tidsskriftReviewForskningpeer review


The gut microbiota is believed to affect a wide variety of mental disorders, including depression. The hypothesis involves bacterial signalling to the host through metabolic, endocrinal, immunologic and neuronal pathways. Few studies of patients with depression have shown altered microbiota profiles and increased levels of systemic endotoxin, which can be detected by leucocytes and result in expression of cytokines. Studies performed so far have lacked statistical power and provide no causal explanation for the gut-brain hypothesis. Further research into the matter is certainly warranted.

TidsskriftUgeskrift for laeger
Udgave nummer47
StatusUdgivet - 20 nov. 2017


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