Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature

Lauge Hjorth Mikkelsen, Simon Andreasen, Linea Cecilie Melchior, Marta Persson, Jeppe Dyrberg Andersen, Vania Pereira, Peter Bjerre Toft, Niels Morling, Göran Stenman, Steffen Heegaard*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Abstract

The aim of the present study was to report the genetic and immunohistochemical profile of a rare case of lacrimal gland oncocytoma. A 20-year-old male underwent magnetic resonance imaging (MRI) due to viral encephalitis. Notably, the MRI revealed a multicystic tumor in the left lacrimal gland. A lateral orbitotomy was performed and the tumor was completely excised. Four months following surgery, the patient was free of symptoms. Histopathologically, the tumor was composed of large, eosinophilic and polyhedral cells with small round nuclei. The tumor cells stained strongly for antimitochondrial antibody MU213-UC, cytokeratin (CK) 5/6, CK 7, CK 17, CK 8/18 and CK 19. The final diagnosis was an oncocytoma of the lacrimal gland without any signs of malignancy. Array-based comparative genomic hybridisation demonstrated a gain of one copy of chromosome 8 and loss of one copy of chromosome 22 as the sole genomic imbalances. These chromosomal alterations have not previously been identified in oncocytoma and may be specific to lacrimal gland oncocytoma. Sequencing of the mitochondrial genome demonstrated multiple alterations of the NADH-ubiquinone oxidoreductase chain 5 (ND5) gene involved in mitochondrial oxidative phosphorylation. This may support the notion of a common genetic background of oncocytic lesions in the lacrimal gland and other anatomical sites.

OriginalsprogEngelsk
Sider (fra-til)4176-4182
Antal sider7
TidsskriftOncology Letters
Vol/bind14
Udgave nummer4
DOI
StatusUdgivet - 1 jan. 2017

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Udforsk hvilke forskningsemner 'Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature' indeholder.

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