Further studies on Hb canebière [β12(G4)Asn→His], a low affinity hemoglobin variant

Ulf Froelund; Erik Sandbakken; Pal Szecsi; Henrik Birgens

doi:10.3109/03630269.2010.511593

Further studies on Hb canebière [β12(G4)Asn→His], a low affinity hemoglobin variant

Ulf Froelund, Erik Sandbakken, Pal Szecsi, Henrik Birgens^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

A case of Hb Canebire [β102(G4)Asn→His] was diagnosed in an otherwise healthy 21-year-old Danish woman. The clinical consequences were minor, since her only symptom consisted of transient cyanosis in lips and fingers when exposed to cold environments. Whole blood p50 was 59.9 mmHg. The Hb Canebire variant could not be separated from Hb A by high performance liquid chromatography (HPLC) and isoelectric focusing (IEF), and it was thus missed by routine hemoglobin (Hb) fractionation techniques.

Originalsprog	Engelsk
Sider (fra-til)	495-499
Antal sider	5
Tidsskrift	Hemoglobin
Vol/bind	34
Udgave nummer	5
DOI	https://doi.org/10.3109/03630269.2010.511593
Status	Udgivet - 1 okt. 2010

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abstract = "A case of Hb Canebire [β102(G4)Asn→His] was diagnosed in an otherwise healthy 21-year-old Danish woman. The clinical consequences were minor, since her only symptom consisted of transient cyanosis in lips and fingers when exposed to cold environments. Whole blood p50 was 59.9 mmHg. The Hb Canebire variant could not be separated from Hb A by high performance liquid chromatography (HPLC) and isoelectric focusing (IEF), and it was thus missed by routine hemoglobin (Hb) fractionation techniques.",

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T1 - Further studies on Hb canebière [β12(G4)Asn→His], a low affinity hemoglobin variant

AU - Froelund, Ulf

AU - Sandbakken, Erik

AU - Szecsi, Pal

AU - Birgens, Henrik

PY - 2010/10/1

Y1 - 2010/10/1

N2 - A case of Hb Canebire [β102(G4)Asn→His] was diagnosed in an otherwise healthy 21-year-old Danish woman. The clinical consequences were minor, since her only symptom consisted of transient cyanosis in lips and fingers when exposed to cold environments. Whole blood p50 was 59.9 mmHg. The Hb Canebire variant could not be separated from Hb A by high performance liquid chromatography (HPLC) and isoelectric focusing (IEF), and it was thus missed by routine hemoglobin (Hb) fractionation techniques.

AB - A case of Hb Canebire [β102(G4)Asn→His] was diagnosed in an otherwise healthy 21-year-old Danish woman. The clinical consequences were minor, since her only symptom consisted of transient cyanosis in lips and fingers when exposed to cold environments. Whole blood p50 was 59.9 mmHg. The Hb Canebire variant could not be separated from Hb A by high performance liquid chromatography (HPLC) and isoelectric focusing (IEF), and it was thus missed by routine hemoglobin (Hb) fractionation techniques.

KW - Codon 102

KW - Hb Canebire

KW - Low-affinity hemoglobin (Hb) variant

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DO - 10.3109/03630269.2010.511593

M3 - Article

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AN - SCOPUS:77956918993

SN - 0363-0269

VL - 34

SP - 495

EP - 499

JO - Hemoglobin

JF - Hemoglobin

IS - 5

ER -

Further studies on Hb canebière [β12(G4)Asn→His], a low affinity hemoglobin variant

Abstract

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