Functional MRI of CO2 induced increase in cerebral perfusion

Egill Rostrup; Henrik B.W. Larsson; Peter B. Toft; Kim Garde; Carsten Thomsen; Poul Ring; Lars Søndergaard; Ole Henriksen

doi:10.1002/nbm.1940070106

Functional MRI of CO₂ induced increase in cerebral perfusion

Egill Rostrup^*, Henrik B.W. Larsson, Peter B. Toft, Kim Garde, Carsten Thomsen, Poul Ring, Lars Søndergaard, Ole Henriksen

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

The sensitivity of MR gradient echo imaging towards CO₂ induced changes in cerebral blood flow was investigated in 10 normal subjects. The subjects were inhaling 5% and 7% CO₂ and the experiments were carried out at 1.5T (n=6) and 2.0 T (n=5), allowing a comparison of field strengths. Additional experiments were carried out using a higher spatial resolution. The largest signal increases were noted in areas corresponding to larger vessels, but significant changes were also conspicuous in deeper cortical and central grey matter. The changes appeared linearly related to the arterial CO₂ tension, within the range of P_aCO₂ studied. In white matter, the changes were not statistically significant.

Originalsprog	Engelsk
Sider (fra-til)	29-34
Antal sider	6
Tidsskrift	NMR in Biomedicine
Vol/bind	7
Udgave nummer	1-2
DOI	https://doi.org/10.1002/nbm.1940070106
Status	Udgivet - mar. 1994

Adgang til dokumentet

10.1002/nbm.1940070106

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http://www.scopus.com/inward/record.url?scp=0028395368&partnerID=8YFLogxK

Citationsformater

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title = "Functional MRI of CO2 induced increase in cerebral perfusion",

abstract = "The sensitivity of MR gradient echo imaging towards CO2 induced changes in cerebral blood flow was investigated in 10 normal subjects. The subjects were inhaling 5% and 7% CO2 and the experiments were carried out at 1.5T (n=6) and 2.0 T (n=5), allowing a comparison of field strengths. Additional experiments were carried out using a higher spatial resolution. The largest signal increases were noted in areas corresponding to larger vessels, but significant changes were also conspicuous in deeper cortical and central grey matter. The changes appeared linearly related to the arterial CO2 tension, within the range of PaCO2 studied. In white matter, the changes were not statistically significant.",

author = "Egill Rostrup and Larsson, {Henrik B.W.} and Toft, {Peter B.} and Kim Garde and Carsten Thomsen and Poul Ring and Lars S{\o}ndergaard and Ole Henriksen",

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doi = "10.1002/nbm.1940070106",

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AU - Rostrup, Egill

AU - Larsson, Henrik B.W.

AU - Toft, Peter B.

AU - Garde, Kim

AU - Thomsen, Carsten

AU - Ring, Poul

AU - Søndergaard, Lars

AU - Henriksen, Ole

PY - 1994/3

Y1 - 1994/3

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AB - The sensitivity of MR gradient echo imaging towards CO2 induced changes in cerebral blood flow was investigated in 10 normal subjects. The subjects were inhaling 5% and 7% CO2 and the experiments were carried out at 1.5T (n=6) and 2.0 T (n=5), allowing a comparison of field strengths. Additional experiments were carried out using a higher spatial resolution. The largest signal increases were noted in areas corresponding to larger vessels, but significant changes were also conspicuous in deeper cortical and central grey matter. The changes appeared linearly related to the arterial CO2 tension, within the range of PaCO2 studied. In white matter, the changes were not statistically significant.

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DO - 10.1002/nbm.1940070106

M3 - Article

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SN - 0952-3480

VL - 7

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EP - 34

JO - NMR in Biomedicine

JF - NMR in Biomedicine

IS - 1-2