Fourier analysis of cerebrospinal fluid flow velocities: MR imaging study

C. Thomsen*, F. Stahlberg, M. Stubgaard, B. Nordell

*Corresponding author af dette arbejde

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    An interleaved pseudocinematographic FLASH (fast low-angle shot) sequence with additional pulsed gradients for flow encoding was used to quantify cerebrospinal fluid (CSF) flow velocities and CSF production. Flow-dependent phase information was obtained by subtracting two differently encoded phase images. The phase information in the resultant image was converted to flow velocity with a calibration curve with the slope 26.5 radian · m-1 · sec. The velocity versus time function was Fourier transformed and a continuous curve was fitted to the measured data with use of the first three harmonics. The in vivo measurements showed a significant variation in flow velocities in the cerebral aqueduct (range, 6-51 mm/sec). Calculated CSF production was in the range of 0.6-1.2 L/24 h. The present method gives valuable information about CSF hydrodynamics in an imaging time of less than 8 minutes.

    Sider (fra-til)659-665
    Antal sider7
    Udgave nummer3
    StatusUdgivet - 1 jan. 1990


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