Follicle development during the normal menstrual cycle

N. S. MacKlon, B. C.J.M. Fauser

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstract

    An understanding of the factors which determine initiation of follicle growth, recruitment and dominant follicle selection may increase our understanding of the underlying process of ovarian aging. In this article, these aspects of the normal menstrual cycle are reviewed. The morphological and endocrinological development in the early follicle is described from the primordial follicle stage. The degree of follicle-stimulating hormone (FSH) dependency is discussed, as is the relationship of estradiol (E2) production to follicle diameter. The principles governing mono-follicular selection are outlined, and the FSH 'threshold' and 'window' concepts are highlighted. Maximum FSH levels in the early follicular phase are shown to be variable between individuals. The relevance of this and the means by which individual sensitivity to FSH may be altered at the ovary in the context of ovarian aging are discussed. Copyright (C) 1998 Elsevier Science Ireland Ltd.

    OriginalsprogEngelsk
    Sider (fra-til)181-188
    Antal sider8
    TidsskriftMaturitas
    Vol/bind30
    Udgave nummer2
    DOI
    StatusUdgivet - 12 okt. 1998

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