Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood-A Randomized Clinical Trial

Laerke Sass; Elín Bjarnadóttir; Jakob Stokholm; Bo Chawes; Rebecca K Vinding; Anna-Rosa C Mora-Jensen; Jonathan Thorsen; Sarah Noergaard; Bjørn H Ebdrup; Jens R M Jepsen; Birgitte Fagerlund; Klaus Bønnelykke; Lotte Lauritzen; Hans Bisgaard

doi:10.1111/cdev.13541

Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood-A Randomized Clinical Trial

Laerke Sass, Elín Bjarnadóttir, Jakob Stokholm, Bo Chawes, Rebecca K Vinding, Anna-Rosa C Mora-Jensen, Jonathan Thorsen, Sarah Noergaard, Bjørn H Ebdrup, Jens R M Jepsen, Birgitte Fagerlund, Klaus Bønnelykke, Lotte Lauritzen, Hans Bisgaard

Børne- og Ungeafdelingen

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

A double-blind randomized controlled trial of n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC2010 mother-child cohort consisting of 736 women and their children. The objective was to determine if maternal n-3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n-3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n-3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.

Originalsprog	Engelsk
Sider (fra-til)	1624-1635
Antal sider	12
Tidsskrift	Child Development
Vol/bind	92
Udgave nummer	4
Tidlig onlinedato	28 jan. 2021
DOI	https://doi.org/10.1111/cdev.13541
Status	Udgivet - jul. 2021

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10.1111/cdev.13541

Citationsformater

Sass, L., Bjarnadóttir, E., Stokholm, J., Chawes, B., Vinding, R. K., Mora-Jensen, A.-R. C., Thorsen, J., Noergaard, S., Ebdrup, B. H., Jepsen, J. R. M., Fagerlund, B., Bønnelykke, K., Lauritzen, L., & Bisgaard, H. (2021). Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood-A Randomized Clinical Trial. Child Development, 92(4), 1624-1635. https://doi.org/10.1111/cdev.13541

@article{903367df43124ad482f1403f1d91ba56,

title = "Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood-A Randomized Clinical Trial",

abstract = "A double-blind randomized controlled trial of n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC2010 mother-child cohort consisting of 736 women and their children. The objective was to determine if maternal n-3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n-3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n-3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.",

author = "Laerke Sass and El{\'i}n Bjarnad{\'o}ttir and Jakob Stokholm and Bo Chawes and Vinding, {Rebecca K} and Mora-Jensen, {Anna-Rosa C} and Jonathan Thorsen and Sarah Noergaard and Ebdrup, {Bj{\o}rn H} and Jepsen, {Jens R M} and Birgitte Fagerlund and Klaus B{\o}nnelykke and Lotte Lauritzen and Hans Bisgaard",

note = "{\textcopyright} 2021 Society for Research in Child Development.",

year = "2021",

month = jul,

doi = "10.1111/cdev.13541",

language = "English",

volume = "92",

pages = "1624--1635",

journal = "Child Development",

issn = "0009-3920",

publisher = "Wiley-Blackwell",

number = "4",

}

Sass, L, Bjarnadóttir, E , Stokholm, J, Chawes, B, Vinding, RK, Mora-Jensen, A-RC, Thorsen, J, Noergaard, S, Ebdrup, BH, Jepsen, JRM, Fagerlund, B, Bønnelykke, K, Lauritzen, L & Bisgaard, H 2021, 'Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood-A Randomized Clinical Trial', Child Development, bind 92, nr. 4, s. 1624-1635. https://doi.org/10.1111/cdev.13541

TY - JOUR

T1 - Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood-A Randomized Clinical Trial

AU - Sass, Laerke

AU - Bjarnadóttir, Elín

AU - Stokholm, Jakob

AU - Chawes, Bo

AU - Vinding, Rebecca K

AU - Mora-Jensen, Anna-Rosa C

AU - Thorsen, Jonathan

AU - Noergaard, Sarah

AU - Ebdrup, Bjørn H

AU - Jepsen, Jens R M

AU - Fagerlund, Birgitte

AU - Bønnelykke, Klaus

AU - Lauritzen, Lotte

AU - Bisgaard, Hans

PY - 2021/7

Y1 - 2021/7

N2 - A double-blind randomized controlled trial of n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC2010 mother-child cohort consisting of 736 women and their children. The objective was to determine if maternal n-3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n-3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n-3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.

AB - A double-blind randomized controlled trial of n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC2010 mother-child cohort consisting of 736 women and their children. The objective was to determine if maternal n-3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n-3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n-3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.

U2 - 10.1111/cdev.13541

DO - 10.1111/cdev.13541

M3 - Article

C2 - 33506965

SN - 0009-3920

VL - 92

SP - 1624

EP - 1635

JO - Child Development

JF - Child Development

IS - 4

ER -

Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood-A Randomized Clinical Trial

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