Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood-A Randomized Clinical Trial

Laerke Sass, Elín Bjarnadóttir, Jakob Stokholm, Bo Chawes, Rebecca K Vinding, Anna-Rosa C Mora-Jensen, Jonathan Thorsen, Sarah Noergaard, Bjørn H Ebdrup, Jens R M Jepsen, Birgitte Fagerlund, Klaus Bønnelykke, Lotte Lauritzen, Hans Bisgaard

Publikation: Bidrag til tidsskriftArtikelForskningpeer review

Abstract

A double-blind randomized controlled trial of n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC2010 mother-child cohort consisting of 736 women and their children. The objective was to determine if maternal n-3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n-3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n-3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.

OriginalsprogEngelsk
Sider (fra-til)1624-1635
Antal sider12
TidsskriftChild Development
Vol/bind92
Udgave nummer4
Tidlig onlinedato28 jan. 2021
DOI
StatusUdgivet - jul. 2021

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