Final Results of a Study Evaluating the Course of Distress Scores During Radiotherapy for Malignant Diseases

Cansu Delikanli; Stefan Janssen; Søren Tvilsted; Nathan Y Yu; Dirk Rades

doi:10.21873/anticanres.16604

Final Results of a Study Evaluating the Course of Distress Scores During Radiotherapy for Malignant Diseases

Cansu Delikanli, Stefan Janssen, Søren Tvilsted, Nathan Y Yu, Dirk Rades^*

^*Corresponding author af dette arbejde

Stab og Ledelse

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

BACKGROUND/AIM: Patients who receive radiotherapy (RT) may experience significant distress. This study investigated distress scores during RT for a variety of malignancies.

PATIENTS AND METHODS: Distress thermometers (scores of 0-10 points) were completed by 927 patients at baseline and end of RT. Six characteristics were evaluated for changes of distress scores including age, sex, Karnofsky performance score (KPS), tumor type, intent of treatment, and previous RT.

RESULTS: Mean distress scores were 4.9 (±2.7) at baseline and 4.6 (±2.7) at the end of RT; mean change was -0.3 (±2.8) points. On univariable analysis, increased distress (≥2 points) was significantly associated with KPS 90-100 (p<0.001) and curative intent (p=0.040). Trends were found for age ≤64 years (p=0.062), head-and-neck cancer (p=0.076), and no prior RT (p=0.055). In patients with baseline scores ≤5 points, deterioration rates were 30-47%.

CONCLUSION: Psychological support should be offered to all patients undergoing RT. This would benefit particularly patients with risk factors for increased distress.

Originalsprog	Engelsk
Sider (fra-til)	4143-4148
Antal sider	6
Tidsskrift	Anticancer Research
Vol/bind	43
Udgave nummer	9
DOI	https://doi.org/10.21873/anticanres.16604
Status	Udgivet - sep. 2023

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10.21873/anticanres.16604Licens: CC BY-NC-ND

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title = "Final Results of a Study Evaluating the Course of Distress Scores During Radiotherapy for Malignant Diseases",

abstract = "BACKGROUND/AIM: Patients who receive radiotherapy (RT) may experience significant distress. This study investigated distress scores during RT for a variety of malignancies.PATIENTS AND METHODS: Distress thermometers (scores of 0-10 points) were completed by 927 patients at baseline and end of RT. Six characteristics were evaluated for changes of distress scores including age, sex, Karnofsky performance score (KPS), tumor type, intent of treatment, and previous RT.RESULTS: Mean distress scores were 4.9 (±2.7) at baseline and 4.6 (±2.7) at the end of RT; mean change was -0.3 (±2.8) points. On univariable analysis, increased distress (≥2 points) was significantly associated with KPS 90-100 (p<0.001) and curative intent (p=0.040). Trends were found for age ≤64 years (p=0.062), head-and-neck cancer (p=0.076), and no prior RT (p=0.055). In patients with baseline scores ≤5 points, deterioration rates were 30-47%.CONCLUSION: Psychological support should be offered to all patients undergoing RT. This would benefit particularly patients with risk factors for increased distress.",

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author = "Cansu Delikanli and Stefan Janssen and S{\o}ren Tvilsted and Yu, {Nathan Y} and Dirk Rades",

year = "2023",

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AU - Delikanli, Cansu

AU - Janssen, Stefan

AU - Tvilsted, Søren

AU - Yu, Nathan Y

AU - Rades, Dirk

PY - 2023/9

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N2 - BACKGROUND/AIM: Patients who receive radiotherapy (RT) may experience significant distress. This study investigated distress scores during RT for a variety of malignancies.PATIENTS AND METHODS: Distress thermometers (scores of 0-10 points) were completed by 927 patients at baseline and end of RT. Six characteristics were evaluated for changes of distress scores including age, sex, Karnofsky performance score (KPS), tumor type, intent of treatment, and previous RT.RESULTS: Mean distress scores were 4.9 (±2.7) at baseline and 4.6 (±2.7) at the end of RT; mean change was -0.3 (±2.8) points. On univariable analysis, increased distress (≥2 points) was significantly associated with KPS 90-100 (p<0.001) and curative intent (p=0.040). Trends were found for age ≤64 years (p=0.062), head-and-neck cancer (p=0.076), and no prior RT (p=0.055). In patients with baseline scores ≤5 points, deterioration rates were 30-47%.CONCLUSION: Psychological support should be offered to all patients undergoing RT. This would benefit particularly patients with risk factors for increased distress.

AB - BACKGROUND/AIM: Patients who receive radiotherapy (RT) may experience significant distress. This study investigated distress scores during RT for a variety of malignancies.PATIENTS AND METHODS: Distress thermometers (scores of 0-10 points) were completed by 927 patients at baseline and end of RT. Six characteristics were evaluated for changes of distress scores including age, sex, Karnofsky performance score (KPS), tumor type, intent of treatment, and previous RT.RESULTS: Mean distress scores were 4.9 (±2.7) at baseline and 4.6 (±2.7) at the end of RT; mean change was -0.3 (±2.8) points. On univariable analysis, increased distress (≥2 points) was significantly associated with KPS 90-100 (p<0.001) and curative intent (p=0.040). Trends were found for age ≤64 years (p=0.062), head-and-neck cancer (p=0.076), and no prior RT (p=0.055). In patients with baseline scores ≤5 points, deterioration rates were 30-47%.CONCLUSION: Psychological support should be offered to all patients undergoing RT. This would benefit particularly patients with risk factors for increased distress.

KW - Humans

KW - Middle Aged

KW - Radiation Oncology

KW - Neoplasms/radiotherapy

KW - Karnofsky Performance Status

KW - Risk Factors

KW - Syndrome

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DO - 10.21873/anticanres.16604

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VL - 43

SP - 4143

EP - 4148

JO - Anticancer Research

JF - Anticancer Research

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ER -

Final Results of a Study Evaluating the Course of Distress Scores During Radiotherapy for Malignant Diseases

Abstract

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