Female reproductive ageing: current knowledge and future trends

Frank J. Broekmans*, Erik A.H. Knauff, Egbert R. te Velde, Nick S. Macklon, Bart C. Fauser

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftReviewForskningpeer review


    Over the past few decades, postponement of childbearing has led to a decrease in family size and increased rates of age-related female subfertility. Age-related decrease in ovarian follicle numbers and a decay in oocyte quality dictate the occurrence of natural loss of fecundity and, ultimately, menopause. The rate of this ovarian ageing process is highly variable among women. Identification of women who have severely decreased ovarian reserve for their age is, therefore, clinically relevant. Endocrine and imaging tests for ovarian reserve relate mainly to the quantitative aspect of ovarian reserve, but their capacity to predict the chances for pregnancy is limited. Genetic factors regulating the size of the follicle pool and the rate of its depletion might be identified in the near future and, possibly, assist the accurate prediction of a woman's reproductive lifespan.

    Sider (fra-til)58-65
    Antal sider8
    TidsskriftTrends in Endocrinology and Metabolism
    Udgave nummer2
    StatusUdgivet - 1 mar. 2007


    Udforsk hvilke forskningsemner 'Female reproductive ageing: current knowledge and future trends' indeholder.