Fatal virus-associated hemophagocytic syndrome associated with coexistent chronic active hepatitis B and acute hepatitis C virus infection

Mikkel Faurschou*, Ove Juul Nielsen, Per Boye Hansen, Birgitte Ravn Juhl, Hans Hasselbalch

*Corresponding author af dette arbejde

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review

    Abstrakt

    A 28-year-old man was admitted to our department with intermittent fever, hepatosplenomegaly and pancytopenia. Liver parameters and serum ferritin were markedly elevated. Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus- associated hemophagocytic syndrome (VAHS). There was serological evidence of chronic active hepatitis B and acute hepatitis C virus infection. The patient died despite aggressive immunosuppressive and supportive treatment. Autopsy revealed signs of acute viral hepatitis with cholestasis. Histiocytes engaged in hemophagocytosis were observed in bone marrow and spleen. The condition was interpreted as VAHS associated with chronic active hepatitis B and acute hepatitis C virus infection. To our knowledge this is the first report of a hemophagocytic syndrome in that setting.

    OriginalsprogEngelsk
    Sider (fra-til)135-138
    Antal sider4
    TidsskriftAmerican Journal of Hematology
    Vol/bind61
    Udgave nummer2
    DOI
    StatusUdgivet - 9 jun. 1999

    Fingeraftryk

    Udforsk hvilke forskningsemner 'Fatal virus-associated hemophagocytic syndrome associated with coexistent chronic active hepatitis B and acute hepatitis C virus infection' indeholder.

    Citationsformater