Fat Grafting With Expanded Adipose-derived Stromal Cells for Breast Augmentation: A Randomized Controlled Trial

Peter V Vester-Glowinski*, Mikkel Herly, Mathias Ørholt, Bo S Rasmussen, Felix C Müller, Jens J Elberg, Carsten Thomsen, Krzysztof T Drzewiecki

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftArtikelForskningpeer review


BACKGROUND: The main challenge with fat grafting is that a varying part of the graft is lost to post-surgery resorption. Previous studies suggest that adipose-derived stromal cells (ASCs) can improve the volume retention of fat grafts but there is a lack of randomized trials to support its use in clinical practice.

OBJECTIVES: This trial aimed to investigate whether ASCs improve fat graft volume retention in patients undergoing breast augmentation with lipofilling.

METHODS: This was a double-blind, randomized controlled trial of breast augmentation with ASC-enriched fat grafting. Healthy women aged 30-45 years were enrolled. First, the participants underwent liposuction to obtain fat for culture expansion of ASCs. Then, the participants were randomized to undergo a 300-350 cc breast augmentation with ASC-enriched fat grafting to one of their breasts and placebo-enriched fat grafting with identical volume to the contralateral breast. A dose of 10 x 10 6 ASCs/mL fat graft was applied. The primary outcome was fat graft volume retention after 1 year's follow-up measured with MRI. The trial is registered at w ww.clinicaltrialsregister.eu (EudraCT-2014-000510-59).

RESULTS: Ten participants were included in the trial; all completed the treatment and follow-up. No serious adverse events occurred. Fat graft volume retention after 1 year was 54.0% [95% CI 30.4-77.6] in the breasts treated with ASC-enriched fat grafting (n=10) and 55.9% [95% CI 28.9-82.9] in the contralateral breasts treated with placebo-enriched fat grafting (n=10) (p=0.566).

CONCLUSIONS: The findings of this trial do not support that ASC-enriched fat grafting is superior to standard fat grafting for breast augmentation.

TidsskriftAesthetic Surgery Journal
StatusUdgivet, E-publikation før trykning - 15 jun. 2022

Bibliografisk note

© The Author(s) 2022. Published by Oxford University Press on behalf of The Aesthetic Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.


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