Farmakologisk behandling af osteitis deformans (Pagets knoglesygdom)

Though most patients with osteitis deformans (OD) are asymptomatic, the disease may cause pain, deformity and a number of complications. Calcitonin and several bisphosphonates decrease bone turnover in OD and may be ranked according to efficacy; nasal calcitonin < intramuscular calcitonin < oral etidronate < intravenous pamidronate, alendronate, risedronate or zolendronat, and oral alendronate or risedronate. Patients with symptoms, neurological complications or lesions in weight-bearing bones in conjunction with increased bone turnover should be treated with bisphosphonates.