Factors associated with the prescription of antidepressive medication to breast cancer patients

Nis P. Suppli, Isabelle Deltour, Lars H. Damkjær, Jane Christensen, Anders B. Jensen, Niels T. Kroman, Christoffer Johansen, Susanne O. Dalton

    Publikation: Bidrag til tidsskriftArtikelForskningpeer review


    We evaluated factors associated with use of antidepressant medication subsequent to a diagnosis of breast cancer. We also evaluated the effect of participation in a cancer rehabilitation program on use of antidepressants. Material and methods. We conducted a register-based cohort study of 1 247 women with breast cancer diagnosed between 1998 and 2006 who attended a week-long rehabilitation program and a comparison group of 2 903 women who did not attend the program matched through the registers of the Danish Breast Cancer Cooperative Group. The associations between breast cancer-related, treatment-related, and sociodemographic factors and use of antidepressants were evaluated in multivariate Cox proportional hazard models separated on use of antidepressants before diagnosis of breast cancer. Results. The mean follow-up for the 4 150 women in the study was 3.3 years (595% range, 0.37.0 years) and 1 020 (25%) were users of antidepressants after diagnosis of breast cancer. Among women who had not used antidepressants before their breast cancer, the diagnosis of a new primary cancer increased the adjusted hazard ratio (HR) to 3.34 (95% CI, 1.507.76), and recurrence of breast cancer increased the HR for first use of antidepressants to 2.56 (95% CI, 1.863.52). Unemployment was associated significantly with use of antidepressants, whereas having no children living at home, lower income, and the number of tumor-positive axillary lymph nodes were of borderline significance. No effect of the rehabilitation program was observed on first use of antidepressants after breast cancer. Discussion. Diagnosis of a new cancer or recurrence of breast cancer considerably increased the rate of use of antidepressants. Sociodemographic rather than disease- or treatment-related characteristics at the time of diagnosis were associated with first use of antidepressants after a breast cancer diagnosis.

    Sider (fra-til)243-251
    Antal sider9
    TidsskriftActa Oncologica
    Udgave nummer2
    StatusUdgivet - 1 feb. 2011


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