TY - JOUR
T1 - External validity of a cardiovascular screening including a coronary artery calcium examination in middle-aged individuals from the general population
AU - Grønhøj, Mette H.
AU - Gerke, Oke
AU - Mickley, Hans
AU - Steffensen, Flemming H.
AU - Lambrechtsen, Jess
AU - Sand, Niels Peter R.
AU - Rasmussen, Lars M.
AU - Olsen, Michael H.
AU - Hallas, Jesper
AU - Diederichsen, Axel C.P.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Background: Coronary artery calcium is important in cardiovascular risk stratification, but this knowledge is based on studies with a significant selection bias. This study aims to evaluate the external validity of a screening programme including coronary artery calcium examination, and the association between coronary artery calcium and cardiovascular events. Design: Multi-centre population based study. Methods: Randomly selected middle-aged men and women (N = 1751) free of cardiovascular disease were invited to the examination during 2009–2010. Participation rate in the examination was 70%. Participants (n = 1227) and non-participants (n = 524) were compared regarding: cardiovascular medical treatment, Charlson comorbidity index and socioeconomic status (evaluated by cohabitation, gross income and education). Study endpoints were cardiovascular events and mortality. Results: Non-participants had a significant higher comorbidity (p = 0.003) and a lower socioeconomic status (p < 0.0001), while cardiovascular medical treatment was alike. Over a median follow-up time of 6.5 years the cardiovascular event and mortality rates were equal (6.7% vs. 6.4%, p = 0.80 and 0.4% vs. 0.5%, p = 0.76, respectively). Adjusted hazard ratio was 0.90 (95% confidence interval (CI) 0.63–1.37). Among participants, the extent of coronary artery calcium was significantly associated with increased risk of cardiovascular events (hazard ratio 1.92, 95% CI 1.03–3.54, hazard ratio 3.66, 95% CI 1.82–7.32, hazard ratio 6.51, 95% CI 3.17–13.36 for coronary artery calcium scores 1–99, 100–399, ≥400 AU, respectively). Conclusions: Non-participants had a higher comorbidity index and a lower socioeconomic status, but the cardiovascular event and mortality rates were equal to those of participants. Thus, a screening programme including a coronary artery calcium examination had a high external validity regarding cardiovascular risk, but also a significant social imbalance.
AB - Background: Coronary artery calcium is important in cardiovascular risk stratification, but this knowledge is based on studies with a significant selection bias. This study aims to evaluate the external validity of a screening programme including coronary artery calcium examination, and the association between coronary artery calcium and cardiovascular events. Design: Multi-centre population based study. Methods: Randomly selected middle-aged men and women (N = 1751) free of cardiovascular disease were invited to the examination during 2009–2010. Participation rate in the examination was 70%. Participants (n = 1227) and non-participants (n = 524) were compared regarding: cardiovascular medical treatment, Charlson comorbidity index and socioeconomic status (evaluated by cohabitation, gross income and education). Study endpoints were cardiovascular events and mortality. Results: Non-participants had a significant higher comorbidity (p = 0.003) and a lower socioeconomic status (p < 0.0001), while cardiovascular medical treatment was alike. Over a median follow-up time of 6.5 years the cardiovascular event and mortality rates were equal (6.7% vs. 6.4%, p = 0.80 and 0.4% vs. 0.5%, p = 0.76, respectively). Adjusted hazard ratio was 0.90 (95% confidence interval (CI) 0.63–1.37). Among participants, the extent of coronary artery calcium was significantly associated with increased risk of cardiovascular events (hazard ratio 1.92, 95% CI 1.03–3.54, hazard ratio 3.66, 95% CI 1.82–7.32, hazard ratio 6.51, 95% CI 3.17–13.36 for coronary artery calcium scores 1–99, 100–399, ≥400 AU, respectively). Conclusions: Non-participants had a higher comorbidity index and a lower socioeconomic status, but the cardiovascular event and mortality rates were equal to those of participants. Thus, a screening programme including a coronary artery calcium examination had a high external validity regarding cardiovascular risk, but also a significant social imbalance.
KW - cardiovascular disease
KW - cardiovascular prevention
KW - Coronary artery calcification
KW - selection bias
KW - socioeconomic status
UR - http://www.scopus.com/inward/record.url?scp=85050558617&partnerID=8YFLogxK
U2 - 10.1177/2047487318774850
DO - 10.1177/2047487318774850
M3 - Article
C2 - 29719966
AN - SCOPUS:85050558617
VL - 25
SP - 1156
EP - 1166
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
SN - 2047-4873
IS - 11
ER -