Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study

Simon Francis Thomsen; Sophie V D Sluis; Lone G Stensballe; Danielle Posthuma; Axel Skytthe; Kirsten O Kyvik; David L Duffy; Vibeke Backer; Hans Bisgaard

doi:10.1164/rccm.200809-1471OC

Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study

Simon Francis Thomsen
, Sophie V D Sluis
, Lone G Stensballe
, Danielle Posthuma
, Axel Skytthe
, Kirsten O Kyvik
, David L Duffy
, Vibeke Backer
, Hans Bisgaard

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

Abstract

BACKGROUND: We explored the nature of the association between severe respiratory syncytial virus (RSV) infection and asthma in a population-based sample of twins. METHODS: Data on hospitalization due to RSV infection was gathered for all twins born in Denmark between 1994 and 2000 (8,280 pairs) and linked to information on asthma obtained from hospital discharge registries and parent-completed questionnaires. Genetic variance components models and direction of causation models were fitted to the observed data. RESULTS: RSV hospitalization and asthma were positively associated (r=0.43) and genetic determinants for the two disorders overlapped completely. Modeling the direction of causation between RSV hospitalization and asthma showed that a model, in which asthma âcausesâ RSV hospitalization fitted the data significantly better (p=0.39 for deterioration in model fit), than a model, in which RSV hospitalization âcausesâ asthma (p

Originalsprog	Engelsk
Sider (fra-til)	1091-7
Antal sider	7
Tidsskrift	American Journal of Respiratory and Critical Care Medicine
Vol/bind	179
Udgave nummer	12
DOI	https://doi.org/10.1164/rccm.200809-1471OC
Status	Udgivet - 12 mar. 2009

Adgang til dokumentet

10.1164/rccm.200809-1471OC

Citationsformater

Thomsen, S. F., Sluis, S. V. D., Stensballe, L. G., Posthuma, D., Skytthe, A., Kyvik, K. O., Duffy, D. L., Backer, V., & Bisgaard, H. (2009). Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study. American Journal of Respiratory and Critical Care Medicine, 179(12), 1091-7. https://doi.org/10.1164/rccm.200809-1471OC

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title = "Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study",

abstract = "BACKGROUND: We explored the nature of the association between severe respiratory syncytial virus (RSV) infection and asthma in a population-based sample of twins. METHODS: Data on hospitalization due to RSV infection was gathered for all twins born in Denmark between 1994 and 2000 (8,280 pairs) and linked to information on asthma obtained from hospital discharge registries and parent-completed questionnaires. Genetic variance components models and direction of causation models were fitted to the observed data. RESULTS: RSV hospitalization and asthma were positively associated (r=0.43) and genetic determinants for the two disorders overlapped completely. Modeling the direction of causation between RSV hospitalization and asthma showed that a model, in which asthma {\^a}causes{\^a} RSV hospitalization fitted the data significantly better (p=0.39 for deterioration in model fit), than a model, in which RSV hospitalization {\^a}causes{\^a} asthma (p",

author = "Thomsen, \{Simon Francis\} and Sluis, \{Sophie V D\} and Stensballe, \{Lone G\} and Danielle Posthuma and Axel Skytthe and Kyvik, \{Kirsten O\} and Duffy, \{David L\} and Vibeke Backer and Hans Bisgaard",

year = "2009",

month = mar,

day = "12",

doi = "10.1164/rccm.200809-1471OC",

language = "English",

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journal = "American Journal of Respiratory and Critical Care Medicine",

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Thomsen, SF, Sluis, SVD, Stensballe, LG, Posthuma, D, Skytthe, A, Kyvik, KO, Duffy, DL, Backer, V & Bisgaard, H 2009, 'Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study', American Journal of Respiratory and Critical Care Medicine, bind 179, nr. 12, s. 1091-7. https://doi.org/10.1164/rccm.200809-1471OC

Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study. / Thomsen, Simon Francis; Sluis, Sophie V D; Stensballe, Lone G et al.
I: American Journal of Respiratory and Critical Care Medicine, Bind 179, Nr. 12, 12.03.2009, s. 1091-7.

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

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T1 - Exploring The Association Between Severe Respiratory Syncytial Virus Infection and Asthma: a Registry-Based Twin Study

AU - Thomsen, Simon Francis

AU - Sluis, Sophie V D

AU - Stensballe, Lone G

AU - Posthuma, Danielle

AU - Skytthe, Axel

AU - Kyvik, Kirsten O

AU - Duffy, David L

AU - Backer, Vibeke

AU - Bisgaard, Hans

PY - 2009/3/12

Y1 - 2009/3/12

N2 - BACKGROUND: We explored the nature of the association between severe respiratory syncytial virus (RSV) infection and asthma in a population-based sample of twins. METHODS: Data on hospitalization due to RSV infection was gathered for all twins born in Denmark between 1994 and 2000 (8,280 pairs) and linked to information on asthma obtained from hospital discharge registries and parent-completed questionnaires. Genetic variance components models and direction of causation models were fitted to the observed data. RESULTS: RSV hospitalization and asthma were positively associated (r=0.43) and genetic determinants for the two disorders overlapped completely. Modeling the direction of causation between RSV hospitalization and asthma showed that a model, in which asthma âcausesâ RSV hospitalization fitted the data significantly better (p=0.39 for deterioration in model fit), than a model, in which RSV hospitalization âcausesâ asthma (p

AB - BACKGROUND: We explored the nature of the association between severe respiratory syncytial virus (RSV) infection and asthma in a population-based sample of twins. METHODS: Data on hospitalization due to RSV infection was gathered for all twins born in Denmark between 1994 and 2000 (8,280 pairs) and linked to information on asthma obtained from hospital discharge registries and parent-completed questionnaires. Genetic variance components models and direction of causation models were fitted to the observed data. RESULTS: RSV hospitalization and asthma were positively associated (r=0.43) and genetic determinants for the two disorders overlapped completely. Modeling the direction of causation between RSV hospitalization and asthma showed that a model, in which asthma âcausesâ RSV hospitalization fitted the data significantly better (p=0.39 for deterioration in model fit), than a model, in which RSV hospitalization âcausesâ asthma (p

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